Evaluation of the cell cycle markers: p-16, cyclin D1 and retinoblastoma in recurrent pleomorphic adenoma

• Grant number: 12/00757-1
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: April 30, 2014
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Andresa Borges Soares
• Grantee: Andresa Borges Soares
• Host Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil

Abstract

Pleomorphic Adenoma (PA) is the most common salivary gland tumor. Recurrent Pleomorphic Adenoma (RPA) occurs presumably when it presents capsule rupture, incomplete resection of microscopic extensions beyond the pseudocapsule or unappreciated multifocal origin. RPA has been associated with the increased risk of malignant transformation to carcinoma ex-adenoma pleomorphic. However, few studies were found on RPA,its biological behavior and risk factors. There are not study about the cell cycle markers - p-16, cyclin D1 and retinoblastoma in recurrent pleomorphic adenoma. Nowadays, the cell cycle markes have received increasing attention, especially because of their importance in biological behavior tumor. The aim of the present study was to investigate the participation of the cell cycle markers - p-16, cyclin D1 and retinoblastoma in PA, RPA and recurrent pleomorphic adenoma with malignant transformation. (AU)