Analysis of promoters for the expression of recombinant proteins in Trichoderma reesei

• Grant number: 12/50153-5
• Support Opportunities: Program for Research on Bioenergy (BIOEN) - Regular Program Grants
• Start date: May 01, 2012
• End date: July 31, 2014
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Felipe Santiago Chambergo Alcalde
• Grantee: Felipe Santiago Chambergo Alcalde
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The highly efficient secretion machinery of the filamentous fungus Trichoderma reesei should be useful for large scale production of homologous or heterologous proteins of industrial interest. We intend to modify a set of metal-induced promoters to allow expression of proteins in large scale using T. reesei as host. The design or identification of such promoters would decrease the production costs of enzymes capable of biomass hydrolysis, and that would help the dissemination of biomass use as source of biocombustible. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHAMBERGO, FELIPE S.; VALENCIA, ESTELA Y.. Fungal biodiversity to biotechnology. Applied Microbiology and Biotechnology, v. 100, n. 6, p. 2567-2577, MAR 2016. (12/50153-5, 14/24107-1)

VALENCIA, ESTELA Y.; CHAMBERGO, FELIPE S.. Mini-review: Brazilian fungi diversity for biomass degradation. Fungal Genetics and Biology, v. 60, p. 10-pg., 2013-11-01. (12/50153-5, 08/57908-6)

VALENCIA, ESTELA Y.; CHAMBERGO, FELIPE S.. Mini-review: Brazilian fungi diversity for biomass degradation. Fungal Genetics and Biology, v. 60, n. SI, p. 9-18, NOV 2013. (12/50153-5, 08/57908-6)