| Grant number: | 11/21366-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | July 01, 2012 |
| End date: | June 30, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Antonio Carlos Cicogna |
| Grantee: | Antonio Carlos Cicogna |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
Abstract
Under pressure overload conditions, the heart undergoes an adaptative process of cardiac remodelation (CR). Among the forms that it presents itself, ventricular hypertrophy stands out. It determines, initially, an improvement in sytolic function, searching cardiac stability maintenance. However, in the longterm picture, CR represents a risk factor for ventricular dysfunction and heart faillure. Among the experimental models available for the study of the effects of pressure overload, supravalvar aortic stenosis stands out for, due to is progressive nature, being the most similar to the equivalent condition in the human being. In this model, several autors have detected diastolic dysfunction in 6 weeks rats. Others have also found a reduction on the protein expression of SERCA2a. However, no study has stablished an objective relationship between the SERCA2a decrease and the drop on the diastolic performance. (AU)
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