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Evaluation of estrogenic potential of soy extract biotransformed in collagen production

Grant number: 12/04225-4
Support type:Regular Research Grants
Duration: July 01, 2012 - June 30, 2015
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Maria Regina Torqueti
Grantee:Maria Regina Torqueti
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Maria José Vieira Fonseca


The socio-economic development of many countries has led to increase life expectancy of the world population, mainly for postmenopausal women. In the first years after the onset of menopause, women have different physical and behavioral manifestations, among them, skin changes which affect theirs quality of life (SPEROFF & FRITZ1, 2005).The hypoestrogenism, due to menopause, accelerates skin deterioration age-related, which results in a reduction on skin thickness, increased number of deep wrinkles and dryness of the skin (BRINCAT2, 2000).Previous studies showed that hormone replacement therapy (HRT) reduces the appearance of deep wrinkles (KOVACS3, 2005) and increase skin thichness (SATOR et al4., 2001).However two big studies, HERS and WHI, questioned the positive effects of HRT and made aware of their adverse effects: increased incidence of breast and endometrial cancer in prolonged treatment (HURLEY et al5., 1998). In the search for alternative therapies to HRT, studies show the effects of phytoestrogens (FEs), because their potential estrogenic effect and structurally similarity to mammalian estrogens and their metabolites (SIMONCINI et al6., 2005; WHITTEN7, 1997). The phytoestrogens are non-steroidal compounds that present among others features the ability to act as an agonist or antagonist of estrogen receptors (ERs) (KUIPER et al8., 1998).Among the Fes, isoflavones extracted from soy have been the focus of recent research, because it contains 1-3 mg of isoflavones per gram of protein (KUIPER et al8; 1998), and as estrogen, exhibit a significant absorption in the skin (HUANG et al9., 2008).In the laboratory of Quality Control of Drugs and Cosmetics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, under the responsibility of Prof. Dr. Maria José Vieira Fonseca, was produced a soy preparation biotransformed by the fungus Aspergillus awamori , that in previous results showed potential and selective antitumor activity and induced the formation of osteoblast (personal communication, unpublished data), parameters relevant to the stage of menopause.Previous studies showned an increase in dermis thickness, in the collagen content and elastic fibers after oral treatment with concentrate soy extract at a dose of 100mg/day (KOTSOPOULOS et al10., 2000; TOMASZEWSKI et al11., 2003). In face of this scenario, we created the hypothesis that this preparation of soy biotransformed can promote estrogenic effect on the skin, increasing the production of collagen and the expression of estrogen receptors. The aim of this study is to develop cosmetic formulations containing soy preparation biotransformed by the fungus Aspergillus awamori and evaluate the effectiveness of these formulations, by the analysis of collagen production and expression of estrogen receptors in culture of cells of human fibroblast. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BEZERRA, PATRICIA HELOISE ALVES; STOCCO, BIANCA; BIANCHI, CAROLINE INACIO; BIANCHINI, FRANCINE; FIGUEIREDO, SONIA APARECIDA; FONSECA, MARIA JOSE VIEIRA; TORQUETI, MARIA REGINA. Soybean extract modified by Aspergillus awamori stimulates a greater collagen-I synthesis in the intracellular matrix of human fibroblasts. Journal of Cosmetic Dermatology, JUN 2021. Web of Science Citations: 0.

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Filed patent(s) as a result of this research project

FORMULAÇÃO COSMÉTICA E SEU USO BR1020160037646 - Universidade de São Paulo (USP) . Maria Regina Torqueti; Bianca Stocco; Maria José Vieira Fonseca; Caroline Inácio Bianch; Francine Junta Bianchini Lima - February 2016, 22