3D dosimetry based on medical images and Monte Carlo codes to use in brachytherapy

• Grant number: 11/22778-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2012
• End date: July 31, 2014
• Field of knowledge: Engineering - Nuclear Engineering - Applications of Radioisotopes
• Principal Investigator: Hélio Yoriyaz
• Grantee: Hélio Yoriyaz
• Host Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Camila Pessoa de Sales ; Felipe Massicano ; Gabriel Paiva Fonseca ; Gisela Menegussi ; Laura Furnari ; Rafael Guedes Possani ; Silvia Radwanski Stuart ; Wladimir Nadalin

Abstract

Recent technological advances have brought several innovations in current brachytherapy procedures, such as radioactive sources and computer-guided three-dimensional planning computer programs, based on magnetic resonance imaging, ultrasound and CT, which enables the planning and implementation of more effective treatments. In this sense, planning systems for cancer treatment using radiation depend fundamentally on physical models and computer programs for estimating dose in patients, where the accuracy of dose estimates plays a critical role in the success or failure of the treatment.Currently, there are no treatment protocols that consider the size of the tumor and organs at risk, this being a matter of great international interest, including Brazil, as shown by international comparison studies such as EMBRACE. Considering this aspect, this present project proposes the development of an integrated system for use in 3D dosimetry of brachytherapy treatment planning, through numerical simulations and experimental measurements. To this end, computational tools will be developed, together with others already in development, to comprise the integrated system as a whole.The project includes the work efforts of three institutions that operate significantly in the area of Medical Physics as follows: IPEN-CNEN/SP, Hospital das Clínicas of the Faculty of Medicine of São Paulo University, USP, and the Maastro Clinic in the Netherlands. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FONSECA, GABRIEL P.; VIANA, RODRIGO S. S.; PODESTA, MARK; RUBO, RODRIGO A.; DE SALES, CAMILA P.; RENIERS, BRIGITTE; YORIYAZ, HELIO; VERHAEGEN, FRANK. HDR Ir-192 source speed measurements using a high speed video camera. Medical Physics, v. 42, n. 1, p. 412-415, JAN 2015. (11/22778-8, 11/01913-4)

FONSECA, GABRIEL P.; RENIERS, BRIGITTE; LANDRY, GUILLAUME; WHITE, SHANE; BELLEZZO, MURILLO; ANTUNES, PAULA C. G.; DE SALES, CAMILA P.; WELTEMAN, EDUARDO; YORIYAZ, HELIO; VERHAEGEN, FRANK. A medical image-based graphical platform-Features, applications and relevance for brachytherapy. BRACHYTHERAPY, v. 13, n. 6, p. 632-639, NOV-DEC 2014. (11/22778-8, 11/23765-7, 11/01913-4)

FONSECA, G. P.; RUBO, R. A.; MINAMISAWA, R. A.; DOS SANTOS, G. R.; ANTUNES, P. C. G.; YORIYAZ, H.. Determination of transit dose profile for a Ir-192 HDR source. Medical Physics, v. 40, n. 5, MAY 2013. (11/22778-8, 11/23765-7, 11/01913-4)

FONSECA, GABRIEL PAIVA; LANDRY, GUILLAUME; WHITE, SHANE; D'AMOURS, MICHEL; YORIYAZ, HELIO; BEAULIEU, LUC; RENIERS, BRIGITTE; VERHAEGEN, FRANK. The use of tetrahedral mesh geometries in Monte Carlo simulation of applicator based brachytherapy dose distributions. Physics in Medicine and Biology, v. 59, n. 19, p. 5921-5935, OCT 7 2014. (11/22778-8, 11/23765-7, 11/01913-4)

FONSECA, GABRIEL PAIVA; TEDGREN, ASA CARLSSON; RENIERS, BRIGITTE; NILSSON, JOSEF; PERSSON, MARIA; YORIYAZ, HELIO; VERHAEGEN, FRANK. Dose specification for Ir-192 high dose rate brachytherapy in terms of dose-to-water-in-medium and dose-to-medium-in-medium. Physics in Medicine and Biology, v. 60, n. 11, p. 4565-4579, JUN 7 2015. (11/22778-8, 11/23765-7, 11/01913-4)

FONSECA, G. P.; LANDRY, G.; RENIERS, B.; HOFFMANN, A.; RUBO, R. A.; ANTUNES, P. C. G.; YORIYAZ, H.; VERHAEGEN, F.. The contribution from transit dose for Ir-192 HDR brachytherapy treatments. Physics in Medicine and Biology, v. 59, n. 7, p. 1831-1844, APR 7 2014. (11/22778-8, 11/23765-7, 11/01913-4)