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Computer simulation based on Monte Carlo method in experimental dosimetry using neutron-activated glass microspheres for brachytherapy application

Grant number: 06/04188-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): April 01, 2007
Effective date (End): August 09, 2009
Field of knowledge:Engineering - Nuclear Engineering
Principal Investigator:Jose Roberto Martinelli
Grantee:Carla da Costa Guimaraes
Host Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil


This proposal intends to use a mathematical modeling to determine the dose distribution in a human liver when neutron activated glass microspheres are directly injected in the organ through an irrigating artery. To accomplish that, the liver and neighbor tissues as well as the radiation source (in the present case, the microspheres) will be mathematically modeled. From this modeling the equivalent dose and the absorbed dose distribution in the damaged region will be evaluated with good accuracy by using the Monte Carlo method. It is proposed the use of the equivalent dose calculation method with a model previously proposed. Further on the dose distribution evaluated by the mathematical modeling will be compared with the experimental data determined from artificial liver and neighbor equivalent tissues. In this case, the experimental absorbed dose will be determined by using thermo luminescent TLD-100 dosimeters, appropriated for this purpose. In the future, this research can be used for applications in malign liver tumor treatments, and therefore it is important the precise dosimetry of the irradiated region since the deviation between the absorbed dose in a specific region should not be more than 5% compared to the dose prescribed by the radiotherapy physician. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUIMARAES, CARLA C.; MORALLES, MAURICIO; SENE, FRANK F.; MARTINELLI, JOSE R.. Dose-rate distribution of P-32-glass microspheres for intra-arterial brachytherapy. Medical Physics, v. 37, n. 2, p. 532-539, . (06/04188-0)
GUIMARÃES‚ C.C.; MORALLES‚ M.; SENE‚ F.F.; MARTINELLI‚ J.R.. Dose-rate distribution of P-glass microspheres for intra-arterial brachytherapy. Medical Physics, v. 37, p. 532, . (06/04188-0)
YORIYAZ‚ H.; MORALLES‚ M.; SIQUEIRA‚ P.T.D.; DA COSTA GUIMARÃES‚ C.; CINTRA‚ F.B.; DOS SANTOS‚ A.. Physical models‚ cross sections‚ and numerical approximations used in MCNP and GEANT4 Monte Carlo codes for photon and electron absorbed fraction calculation. Medical Physics, v. 36, p. 5198, . (06/04188-0)

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