Development of neural control of the cardiovascular system in reptiles

• Grant number: 12/06938-8
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: October 01, 2012
• End date: February 28, 2013
• Field of knowledge: Biological Sciences - Zoology - Physiology of Recent Groups
• Principal Investigator: Augusto Shinya Abe
• Grantee: Augusto Shinya Abe
• Visiting researcher: Edwin Willian Taylor
• Visiting researcher institution: University of Birmingham, England
• Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil

Abstract

The present project is to support the visit of Prof. Dr. Edwin Taylor for 5 months (October 2012 to February 2013) to our laboratory in order to study the cardiovascular physiology of reptiles, and in particular embryonic development. This is the continuation of a collaborative investigation initiated in 2010 that has already produced data being prepared for publication (see the proposal). The collaboration of Dr. Taylor with our laboratory and with others in São Paulo State has extended for more than 10 years and resulted in the publication of more than 20 articles (27 to date with others in preparation - see Appendix 1). He has also participated in several taught courses and attended scientific congresses in SP (see didactic activities listed below). His expertise enables us to use anatomical pharmacological and electrophysiological techniques to study the detailed anatomy and physiology of the heart and its nervous control in reptiles both during development and in adults under controlled conditions in order to determine the establishment of cardiac rhythms and their variability. As well as my personal collaboration the project includes the participation of my postgraduate student Marina Sartori and of Dr. Cleo Alcantara Leite, from the Federal University of São Paulo. We expect Dr. Dane Crossley and members of his lab from the University of North Texas Future to join us during Dr. Taylor's visit. In the medium term our work may extend to the development of genetic markers for development of the heart and its innervation. Present-day reptiles represent a group ancestral the evolution of both birds and mammals. Consequently study of the development and functioning of control of the cardiovascular system in reptiles is likely to provide data important to our understanding of the fundamental functional characteristics of cardiovascular control and in particular of cardiorespiratory interactions in vertebrates. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SARTORI, MARINA R.; LEITE, CLEO A. C.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.; TAYLOR, EDWIN W.. The progressive onset of cholinergic and adrenergic control of heart rate during development in the green iguana, Iguana iguana. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 188, p. 1-8, OCT 2015. (08/57712-4, 12/16537-0, 12/06938-8)

SARTORI, MARINA R.; TAYLOR, EDWIN W.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.. An appraisal of the use of an infrared digital monitoring system for long-term measurement of heart rate in reptilian embryos. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 188, p. 17-21, OCT 2015. (12/16537-0, 12/06938-8)

TAYLOR, EDWIN W.; LEITE, CLEO A. C.; SARTORI, MARINA R.; WANG, TOBIAS; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.. The phylogeny and ontogeny of autonomic control of the heart and cardiorespiratory interactions in vertebrates. Journal of Experimental Biology, v. 217, n. 5, p. 690-703, MAR 2014. (08/57712-4, 12/16537-0, 12/06938-8, 08/00107-1)

SARTORI, MARINA R.; KOHL, ZACHARY F.; TAYLOR, EDWIN W.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.. Convective oxygen transport during development in embryos o the snapping turtle Chelydra serpentina. Journal of Experimental Biology, v. 221, n. 18, SEP 2018. (12/06938-8, 13/05677-9)

SARTORI, MARINA R.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.; TAYLOR, EDWIN W.. Rates of oxygen uptake increase independently of changes in heart rate in late stages of development and at hatching in the green iguana, Iguana iguana. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 205, p. 28-34, MAR 2017. (12/16537-0, 12/06938-8)

SARTORI, MARINA R.; KOHL, ZACHARY F.; TAYLOR, EDWIN W.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.. Blood flow distribution in embryonic common snapping turtles Chelydra serpentina (Reptilia; Chelonia) during acute hypoxia and alpha-adrenergic regulation. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 238, DEC 2019. (12/06938-8, 14/01666-5)

FILOGONIO, RENATO; TAYLOR, EDWIN W.; CARREIRA, LAURA B. T.; LEITE, GABRIELLE S. P. C.; ABE, AUGUSTO S.; LEITE, CLEO A. C.. Systemic Blood Flow Relations in Conscious South American Rattlesnakes. South American Journal of Herpetology, v. 9, n. 3, p. 171-176, DEC 2014. (08/57712-4, 12/06938-8)

SKOVGAARD, NINI; ABE, AUGUSTO S.; TAYLOR, EDWIN W.; WANG, TOBIAS. Cardiovascular effects of histamine in three widely diverse species of reptiles. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL, v. 188, n. 1, p. 153-162, JAN 2018. (12/06938-8)