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Relative blood flow and cardiac output in embryos of the snapping turtle Chelydra serpentina (Reptilia; Chelonia)

Grant number: 14/01666-5
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 01, 2014
Effective date (End): September 30, 2014
Field of knowledge:Biological Sciences - Physiology - Compared Physiology
Principal researcher:Augusto Shinya Abe
Grantee:Marina Rincon Sartori
Supervisor abroad: Dane Alan Crossley II
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
Research place: University of North Texas, United States  
Associated to the scholarship:12/16537-0 - Cardiovascular autonomic control and metabolism in lizard embryos (Reptilia; Lepidosauria), BP.DR


Embryos of amniotes have a unique system of gas exchange in which the chorioallantoic membrane (CAM) acts as the exchange surface, a structure analogous to the mammalian placenta. While circulatory system function of the mammalian fetus is well understood even basic parameters such as heart rate in other amniotic animals remain a mystery. Blood flow during non-mammalian amniotic development is divided into an extra-embryonic circulation, which plays a role in gas exchange in which the oxygen poor blood is exposed to the environment. However, the vascular structure of the CAM lays outside the embryo thus two vascular compartments are present, extra embryonic and inter-embryonic. Blood perfusion of these vascular compartments is therefore differentially regulated with the capacity for blood shunts away from or into each location. Due to the complex arrangement, embryonic circulation is of difficult access, however a minimally invasive technique was developed to overcome this problem, measuring relative blood flow via microspheres distributions. In this study the aim is to determine blood flow and cardiac output of embryonic snapping turtles by the use of the fluorescent microspheres, a technique validated as an accurate method of determination of regional blood flows. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SARTORI, MARINA R.; KOHL, ZACHARY F.; TAYLOR, EDWIN W.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A. Blood flow distribution in embryonic common snapping turtles Chelydra serpentina (Reptilia; Chelonia) during acute hypoxia and alpha-adrenergic regulation. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 238, DEC 2019. Web of Science Citations: 0.

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