Cardiovascular autonomic control and metabolism in lizard embryos (Reptilia; Lepidosauria)

• Grant number: 12/16537-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): January 01, 2013
• Effective date (End): September 04, 2016
• Field of knowledge: Biological Sciences - Physiology - Compared Physiology
• Principal Investigator: Augusto Shinya Abe
• Grantee: Marina Rincon Sartori
• Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
• Associated scholarship(s): 14/01666-5 - Relative blood flow and cardiac output in embryos of the snapping turtle Chelydra serpentina (Reptilia; Chelonia), BE.EP.DR 13/05677-9 - Oxygen consumption and distribution in embryonic snapping turtles (Chelydra serpentina)(Reptilia; Chelonia), BE.EP.DR

Abstract

The cardiovascular control is related to the appropriate oxygen delivery to tissues, according to the metabolic demand of the organism. To ensure the correct supply of oxygen carried by the blood there is a control executed by the autonomic nervous system with its sympathetic and parasympathetic branches. At the embryo phase, the nervous system is in continuous maturation and the mechanisms used for cardiovascular control are not well understood in the group. In reptiles, the oxygen demand changes during embryonic development due to tissue formation and embryo growth. Previous studies show that the oxygen consumption in embryonic reptiles rise along the development in three possible patterns: exponential, sigmoidal and in peak. Thus, cardiovascular adjustments occur throughout the embryonic life, in order to match the oxygen demand of each stage. In this study, the metabolism (VO2), the mechanisms of control of the heart rate by the autonomic nervous system and the localization of the vagal nerve projections in the brainstem will be determined in different embryonic stages and in juveniles or adults of two lizard species, Iguana iguana and Tupinambis merianae. These species are from distinct clades of the Squamata phylogenetic tree. As reptile eggs are susceptible to environmental variations, it will be also determined temperature and gas composition effects in heart rate at the last stages of development.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SARTORI, MARINA R.; LEITE, CLEO A. C.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.; TAYLOR, EDWIN W.. The progressive onset of cholinergic and adrenergic control of heart rate during development in the green iguana, Iguana iguana. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 188, p. 1-8, OCT 2015. (08/57712-4, 12/16537-0, 12/06938-8)

SARTORI, MARINA R.; TAYLOR, EDWIN W.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.. An appraisal of the use of an infrared digital monitoring system for long-term measurement of heart rate in reptilian embryos. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 188, p. 17-21, OCT 2015. (12/16537-0, 12/06938-8)

TAYLOR, EDWIN W.; LEITE, CLEO A. C.; SARTORI, MARINA R.; WANG, TOBIAS; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.. The phylogeny and ontogeny of autonomic control of the heart and cardiorespiratory interactions in vertebrates. Journal of Experimental Biology, v. 217, n. 5, p. 690-703, MAR 2014. (08/57712-4, 12/16537-0, 12/06938-8, 08/00107-1)

BOUKENS, BASTIAAN J. D.; KRISTENSEN, DITTE L.; FILOGONIO, RENATO; CARREIRA, LAURA B. T.; SARTORI, MARINA R.; ABE, AUGUSTO S.; CURRIE, SHANNON; JOYCE, WILLIAM; CONNER, JUSTIN; OPTHOF, TOBIAS; et al. The electrocardiogram of vertebrates: Evolutionary changes from ectothermy to endothermy. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, v. 144, p. 16-29, JUL 2019. (12/16537-0)

FILOGONIO, RENATO; SARTORI, MARINA R.; MORGENSEN, SUSIE; TAVARES, DRIELE; CAMPOS, RAFAEL; ABE, AUGUSTO S.; TAYLOR, EDWIN W.; RODRIGUES, GERSON J.; DE NUCCI, GILBERTO; SIMONSEN, ULF; et al. Cholinergic regulation along the pulmonary arterial tree of the South American rattlesnake: vascular reactivity, muscarinic receptors, and vagal innervation. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 319, n. 2, p. R156-R170, AUG 2020. (12/16537-0)

SARTORI, MARINA R.; ABE, AUGUSTO S.; CROSSLEY, II, DANE A.; TAYLOR, EDWIN W.. Rates of oxygen uptake increase independently of changes in heart rate in late stages of development and at hatching in the green iguana, Iguana iguana. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 205, p. 28-34, MAR 2017. (12/16537-0, 12/06938-8)

GAVIRA, RODRIGO S. B.; SARTORI, MARINA R.; GONTERO-FOURCADE, MANUEL N.; GOMES, BRUNA F.; ABE, AUGUSTO S.; ANDRADE, DENIS V.. The consequences of seasonal fasting during the dormancy of tegu lizards (Salvator merianae) on their postprandial metabolic response. Journal of Experimental Biology, v. 221, n. 8, APR 2018. (11/09647-1, 12/15697-4, 08/57712-4, 13/04190-9, 12/16537-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SARTORI, Marina Rincon. Autonomic cardiovascular control and metabolism in embyonic lizards (Reptilia; Lepidosauria). 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Rio Claro Rio Claro.