Increase in biomarkers of myocardial necrosis after surgical or percutaneous revascularization in the absence of demonstrated myocardial infarction

• Grant number: 11/20876-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2012
• End date: July 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Whady Armindo Hueb
• Grantee: Whady Armindo Hueb
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The detection of elevated cardiac enzyme levels without the occurrence of ECG changes with or without the presence of symptoms after coronary artery bypass grafting with cardiopulmonary bypass (CPB) identifies, by consensus, perioperative myocardial infarction.Because of this, many events of myocardial injury can occur without the ECG is sensitive enough to detect this abnormality. Potential mechanisms of perioperative myocardial necrosis are many and occur mainly by technical conditions or the severity of the patient. This scenario included intermittent clamping of the aorta, with intervention in native coronary artery occlusion or embolism and venous graft.Recent studies have shown that CABG can be performed without the aid of (CPB). Further studies indicate that with this technique, we get better myocardial protection, less cellular and mitochondrial damage, with consequent reduction of cellular necrosis.Additional resources for myocardial revascularization include angioplasty using stent angioplasty. This procedure has also elevated biomarkers of necrosis without ECG changes.Predictors of perioperative myocardial infarction procedure may be related to the quality of the vase, plate or both. Moreover, they may be related to the quality of equipment or instruments. Thus, in order to define the rate of release of enzymes as borderline irreversible damage to consider this study aims to study patients undergoing surgical or percutaneous coronary intervention. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HUEB, WHADY; GERSH, BERNARD J.; REZENDE, PAULO CURY; GARZILLO, CIBELE LARROSA; LIMA, EDUARDO GOMES; VIEIRA, RICARDO D'OLIVEIRA; RAHMI GARCIA, ROSA MARIA; FAVARATO, DESIDERIO; SEGRE, CARLOS ALEXANDRE W.; PEREIRA, ALEXANDRE COSTA; et al. Hypotheses, rationale, design, and methods for prognostic evaluation of cardiac biomarker elevation after percutaneous and surgical revascularization in the absence of manifest myocardial infarction. A comparative analysis of biomarkers and cardiac magnetic resonance. The MASS-V Trial. BMC CARDIOVASCULAR DISORDERS, v. 12, AUG 16 2012. (11/20876-2)

HUEB, WHADY; GERSH, BERNARD J.; ALVES DA COSTA, LEANDRO MENEZES; COSTA OIKAWA, FERNANDO TEIICHI; VIEIRA DE MELO, RODRIGO MOREL; REZENDE, PAULO CURY; GARZILLO, CIBELE LARROSA; LIMA, EDUARDO GOMES; NOMURA, CESAR HIGA; VILLA, ALEXANDRE VOLNEY; et al. Accuracy of Myocardial Biomarkers in the Diagnosis of Myocardial Infarction After Revascularization as Assessed by Cardiac Resonance: The Medicine, Angioplasty, Surgery Study V (MASS-V) Trial. Annals of Thoracic Surgery, v. 101, n. 6, p. 2202-2208, JUN 2016. (11/20876-2)

CARDOSO DE AZEVEDO, DIOGO FREITAS; HUEB, WHADY; LIMA, EDUARDO GOMES; REZENDE, PAULO CURY; LINHARES FILHO, JAIME PAULA PESSOA; DE CARVALHO, GUILHERME FERNANDES; MARTINS, EDUARDO BELLO; NOMURA, CESAR HIGA; CASSARO STRUNZ, CELIA MARIA; SERRANO JUNIOR, CARLOS VICENTE; et al. Significant association of SYNTAX score on release of cardiac biomarkers in uncomplicated post-revascularization procedures among patients with stable multivessel disease MASS-V Study group. MEDICINE, v. 99, n. 8, FEB 2020. (11/20876-2)

MARTINS, EDUARDO BELLO; HUEB, WHADY; BROWN, DAVID L.; SCUDELER, THIAGO LUIS; LIMA, EDUARDO GOMES; REZENDE, PAULO CURY; SOARES, PAULO ROGERIO; GARZILLO, CIBELE LARROSA; LINHARES FILHO, JAIME PAULA PESSOA; BATISTA, DANIEL VALENTE; et al. Surgical and percutaneous revascularization outcomes based on SYNTAX I, II, and residual scores: a long-term follow-up study. JOURNAL OF CARDIOTHORACIC SURGERY, v. 16, n. 1, SEP 3 2021. (11/20876-2)

LINHARES-FILHO, JAIME; HUEB, WHADY; LIMA, EDUARDO; REZENDE, PAULO; AZEVEDO, DIOGO; ROCHITTE, CARLOS; NOMURA, CESAR; SERRANO-JUNIOR, CARLOS; RAMIRES, JOSE; KALIL-FILHO, ROBERTO. Long-term prognostic value of late gadolinium enhancement and periprocedural myocardial infarction after uncomplicated revascularization: MASS-V follow-up. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, v. 23, n. 2, p. 11-pg., 2022-01-24. (11/20876-2)

COSTA OIKAWA, FERNANDO TEIICHI; HUEB, WHADY; NOMURA, CESAR HIGA; HUEB, ALEXANDRE CIAPPINA; VILLA, ALEXANDRE VOLNEY; ALVES DA COSTA, LEANDRO MENEZES; VIEIRA DE MELO, RODRIGO MOREL; REZENDE, PAULO CURY; WAINROBER SEGRE, CARLOS ALEXANDRE; GARZILLO, CIBELE LARROSA; et al. Abnormal elevation of myocardial necrosis biomarkers after coronary artery bypass grafting without established myocardial infarction assessed by cardiac magnetic resonance. JOURNAL OF CARDIOTHORACIC SURGERY, v. 12, DEC 29 2017. (11/20876-2)

DALLAZEN, ANDERSON ROBERTO; REZENDE, PAULO CURY; HUEB, WHADY; HLATKY, MARK ANDREW; NOMURA, CESAR HIGA; ROCHITTE, CARLOS EDUARDO; BOROS, GUSTAVO ANDRE BOEING; RIBAS, FERNANDO FAGLIONI; RIBEIRO, MATHEUS DE OLIVEIRA LATERZA; SCUDELER, THIAGO LUIS; et al. Myocardial microstructure assessed by T1 mapping after on-pump and off-pump coronary artery bypass grafting. JOURNAL OF THORACIC DISEASE, v. N/A, p. 12-pg., 2023-06-05. (11/20876-2)

RIBEIRO, M.; HUEB, W.; REZENDE, P. C.; ROCHITTE, C. E.; NOMURA, C. H.; MORAIS, T.; LIMA, E. G.; BOROS, G. A. B.; RIBAS, F. F.; CARVALHO, F. P. C.; et al. T1 mapping for myocardial tissue evaluation in patients with ischemia and stable coronary artery disease: MASS V-Trial Study Group. EUROPEAN HEART JOURNAL, v. 41, p. 1-pg., 2020-11-01. (11/20876-2)