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Incidence of adverse events in the clinical follow-up of patients involved in the study: therapeutic use of ultrasound in acute and chronic coronary arterial disease: therapeutic use of ultrasound and microbubbles in the recanalization of AMI

Grant number: 20/08933-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2021
Effective date (End): July 31, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Luciene Ferreira Azevedo
Grantee:Isabella Scavariello Zicari Di Monte
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


In acute coronary artery disease, pre-clinical studies have indicated that, during a continuous infusion of intravenous perfluorocarbon containing microbubbles, the ultrasonic power delivered from a diagnostic ultrasound transducer is capable of restoring microcirculatory flow and improving epicardial recanalization rates obtained by conventional therapy, a process known by Sonothrombolysis. Since both diagnostic ultrasound and intravenous infusions of microbubbles are a Class I indication to assess regional and global left ventricular function and risk area in patients with ST segment elevation myocardial infarction, the study examined whether diagnostic assessments of left ventricular function and risk area size impacts epicardial recanalization rates and infarct size in ST segment elevation myocardial infarction. Since coronary artery disease accounts for nearly 20% of deaths worldwide and increasingly consumes nearly 20% of the resources of the National Health System in Brazil, this innovative therapy has the potential to improve treatment outcomes for the various existing Coronary syndromes and reduce the number of hospitalizations and myocardial revascularization in this population of Brazilians. The present study aims to investigate the incidence of adverse events in clinical follow-up of 50 patients treated with Sonothrombolysis and primary angioplasty (ultrasound group) and 50 patients treated with primary angioplasty only (conventional group), involved in the study: THERAPEUTIC USE OF ULTRASOUND IN ACUTE AND CHRONIC CORONARY ARTERY DISEASE, more specifically of substudy 1: Therapeutic Use of Ultrasound and Microbubbles in the recanalization of the acute myocardial infarction. (SDC: 3562/10/151 - CAAE 13386213.5.0000.0068). (AU)

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