High ultrasound mechanical index and microbubbles to reduce acute myocardial infarction burden: myocardial salvage measuring by cardiac magnetic resonance.

• Grant number: 23/06285-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): June 01, 2023
• Effective date (End): May 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Wilson Mathias Júnior
• Grantee: Carolina Takematsu
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 18/06387-8 - High ultrasound mechanical index and microbubbles to reduce acute myocardial infarction burden I. HUBBLE-I study, AP.TEM

Abstract

Cardiovascular diseases accounted for 32% of all deaths in 2019, one of the leading causes of death worldwide. In 2020 approximately 110,000 individuals died from ischemic heart disease in Brazil, including deaths due to acute coronary syndrome (ACS).The main pathophysiological mechanism of ACS is the obstruction of blood flow in the coronary artery by a thrombus. It encompasses several clinical manifestations. Therefore, its therapies have as their main objective the restoration of perfusion of the affected artery.Currently, fibrinolytic therapy and percutaneous coronary intervention are the treatments of choice for acute myocardial infarction with ST-segment elevation (STEMI), one of the manifestations of ACS. However, both therapies have limitations, contraindications and complications. Taking those into consideration, sonothrombolysis has been studied as an adjuvant therapy that seeks to contribute effectively and early to the treatment of ACS. Nonetheless, indepth studies to evaluate the effects of sonothrombolysis and its association with other therapeutic forms such as fibrinolytic therapy and PCI are still needed.The aim of this study is to evaluate the effect of sonothrombolysis on myocardial salvage, using cardiac magnetic resonance imaging in patients with STEMI initially treated with fibrinolytics.