Evaluation of the glaucomatous lesion on the central nervous system by fMRI and the correlation with psychophysics and an atomics retinal findings

• Grant number: 07/07339-2
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2008
• End date: July 31, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Augusto Paranhos Junior
• Grantee: Augusto Paranhos Junior
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

The alterations of the central neural system (CNS)due to glaucoma as an extension of the lesion of the lateral geniculate body ( LGB) has been demonstrated in primate models. And it has been shown that the extension of the lesion was proportional to the lesion on the optic nerve, at least to the Parvo (P) and Magno (M) pathways. Moreover, it had been suggested that once there is a lesion on the CNS, it could collaborate for the glaucoma progression itself. There are also evidences that the transinaptic or trasneuronal degeneration that involves the dissemination of the neuronal lesion to neurons far from the synapses seems to occur also on glaucoma. Only recently, similar degenerative lesions were reported on human SNC. Functional magnetic resonance (fMRI) is actually one of the most used technique for basic and clinical neuroscience. It is capable to locate the site of the neuronal response allowing the identification of eloquent areas, characterization of reorganization patterns after lesions and identification of neuronal function differences between subjects associated with disease susceptibilities. Objective: (1) to analyze the visual cortex alteration of glaucomatous patients when submitted to visual stimulus comparing with normal subjects; (2) to study possible LGB volume modifications of glaucomatous patients comparing with a control group; (3) to compare the results of fMRI with functional response like SAP, SWAP, FDT and chromatic pupilometry; (4) to compare the results of fMRI with anatomical findings of the optic nerve head and retinal nerve fiber layer detected by ocular coherence tomography; (5) to evaluate the cortical response to the stimulus of retinal ganglion cells subpopulations. Methodology: The patients with typical glaucomatous defect on retinal nerve fiber layer (Hoyt sign) and patients with very advanced glaucoma will be submitted to psychophysics tests (SAP, FDT, SWAP), chromatic pupilometry, neuronal images of the LGB and calcarine fissure and fMRI of the V1 area. Evaluation of the correspondence of the anatomic and functional retinal lesion with anatomical and functional cortical lesion will be performed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GERENTE, VANESSA M.; SCHOR, RUTH R.; CHAIM, KHALLIL T.; FELIX, MARCELO DE MARIA; VENTURA, DORA F.; TEIXEIRA, SERGIO H.; LOTTENBERG, CLAUDIO L.; AMARO, JR., EDSON; PARANHOS, JR., AUGUSTO. Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings. PLoS One, v. 10, n. 5, MAY 13 2015. (07/07339-2)