Analysis of gene expression profile of cell proliferation and inflammatory response and the pattern of methylation of tumor suppressor genes p16INK4A and p15INK4b and its implications in the prognosis of peripheral T-cell lymphomas

• Grant number: 12/50495-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2012
• End date: June 30, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Juliana Pereira
• Grantee: Juliana Pereira
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Non-Hodgkin lymphomas of peripheral T cells comprise significant portion of chronic lymphoproliferative malignancies, representing 10-15% of all non-Hodgkin lymphomas. Unlike lymphomas of B immunophenotype, data available in the literature regarding pathogenics and molecular characteristics involved in these diseases are scarce, as well as therapeutic and prognostic determinants. The present study was designed to validate the preliminary data suggesting that overexpression of genes related to proliferation and cell cycle (CCNA2, TOP2A, CHECK1) may be related to unfavorable outcome. In contrast, we assume that the overexpression of genes NFKB1 and VGF1 and underexpression IKBKB gene were correlated with better prognosis. We will analyze also the pattern of CpG methylation of the promoter regions of tumor suppressor genes p16INK4a and p15INK4b trying to determine the prognostic value of hipermetilador phenotype and possible therapeutic role of hypomethylating agents in these tumors. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE PADUA COVAS LAGE, LUIS ALBERTO; BRITO, CLAUDIO VINICIUS; LEVY, DEBORA; CULLER, HEBERT FABRICIO; FREITAS COUTO, SAMUEL CAMPANELLI; ALVES DE OLIVEIRA, LUCAS BASSOLLI; NOGUEIRA ZERBINI, MARIA CLAUDIA; ROCHA, VANDERSON; PEREIRA, JULIANA. Diagnostic and prognostic implications of tumor expression of the GATA-3 gene in nodal peripheral T-cell lymphoma (nPTCL): Retrospective data from a Latin American cohort. Leukemia Research, v. 114, p. 9-pg., 2022-03-01. (12/50495-3)

DE PADUA COVAS LAGE, LUIS ALBERTO; BRITO, CLAUDIO VINICIUS; BARRETO, GUILHERME CARNEIRO; CULLER, HEBERT FABRICIO; REICHERT, CADIELE OLIANA; LEVY, DEBORA; COSTA, RENATA DE OLIVEIRA; NOGUEIRA ZERBINI, MARIA CLAUDIA; ROCHA, VANDERSON; PEREIRA, JULIANA. Up-front Therapy With CHOP Plus Etoposide in Brazilian nodal PTCL Patients: Increased Toxicity and No Survival Benefit Compared to CHOP Regimen-Results of a Real-Life Study From a Middle-Income Country. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, v. 22, n. 11, p. 13-pg., 2022-11-01. (12/50495-3)

DE PADUA COVAS LAGE, LUIS ALBERTO; HAMASAKI, DEBORA TOSHIE; MOREIRA, FREDERICO RAFAEL; ROCHA, VANDERSON; NOGUEIRA ZERBINI, MARIA CLAUDIA; PEREIRA, JULIANA. Absolute monocyte count is a predictor of overall survival and progression-free survival in nodal peripheral T cell lymphoma. ANNALS OF HEMATOLOGY, v. 98, n. 9, p. 2097-2102, SEP 2019. (12/50495-3)

LAGE, LUIS ALBERTO DE PADUA COVAS; CULLER, HEBERT FABRICIO; BARRETO, GUILHERME CARNEIRO; REICHERT, CADIELE OLIANA; LEVY, DEBORA; COSTA, RENATA DE OLIVEIRA; ROCHA, VANDERSON; PEREIRA, JULIANA. Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas. CLINICAL EPIGENETICS, v. 14, n. 1, p. 8-pg., 2022-12-01. (12/50495-3)

DE PADUA COVAS LAGE, LUIS ALBERTO; BARRETO, GUILHERME CARNEIRO; CULLER, HEBERT FABRICIO; CAVALCANTE, JESSICA BILLAR; DE OLIVEIRA ALVES, LUCAS BASSOLLI; NARDINELLI, LUCIANA; BENDIT, ISRAEL; NOGUEIRA ZERBINI, MARIA CLAUDIA; ROCHA, VANDERSON; PEREIRA, JULIANA. TET-2 mutations predict poor outcomes and are associated with unfavorable clinical-biological features in PTCL, not otherwise specified and angioimmunoblastic T-cell lymphoma in Brazilian patients. CANCER BIOMARKERS, v. 35, n. 2, p. 13-pg., 2022-01-01. (12/50495-3)