Participation of adrenergic system in the myocardial dysfunction induced by obesity

• Grant number: 12/16647-0
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2012
• End date: October 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio Carlos Cicogna
• Grantee: Antonio Carlos Cicogna
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The incidence and prevalence of obesity worldwide has increased progressively in recent decades and is now considered a global epidemic and a major public health problem. Several experimental studies have shown that obesity causes myocardial dysfunction in rats. While it is clear that a variety of damage in cardiac performance occurs with obesity, the mechanisms responsible for these changes are not established. Several factors have been suggested as responsible for possible cardiac abnormalities in obesity models, among them, the ²-adrenergic system. Although it is well established that ²-adrenergic receptors and G proteins play important roles in regulating cardiac performance, research has shown that in pathological situations, changes in the expression and/or activity of ²-adrenergic receptors and G protein promote functional abnormalities. In the obesity, non-genetic experimental models, only two studies have been conducted approaching the relationship between cardiac function and ²-adrenergic pathway. Due to the lack of information and studies that evaluated the relationship between obesity and ²-adrenergic pathway in cardiac performance, the purpose of this study is to investigate the role of ²-adrenergic components in the myocardial dysfunction induced by obesity. Our hypothesis is that the functional damage in obese rats was due to lower expression and / or activity of ²-adrenergic receptors, as well as reduced levels of myocardial Gs protein. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TOGNERI FERRON, ARTUR JUNIO; JACOBSEN, BRUNO BARCELLOS; ST ANA, PAULA GRIPPA; SALOME DE CAMPOS, DIJON HENRIQUE; DE TOMASI, LORETA CASQUEL; MELLO LUVIZOTTO, RENATA DE AZEVEDO; CICOGNA, ANTONIO CARLOS; LEOPOLDO, ANDRE SOARES; LIMA-LEOPOLDO, ANA PAULA. Cardiac Dysfunction Induced by Obesity Is Not Related to beta-Adrenergic System Impairment at the Receptor-Signalling Pathway. PLoS One, v. 10, n. 9, SEP 21 2015. (12/16647-0)

VILEIGAS, DANIELLE F.; DE DEUS, ADRIANA F.; DA SILVA, DANIELLE C. T.; DE TOMASI, LORETA C.; DE CAMPOS, DIJON H. S.; ADORNI, CAROLINE S.; DE OLIVEIRA, SCARLET M.; SANT'ANA, PAULA G.; OKOSHI, KATASHI; PADOVANI, CARLOS R.; et al. Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial -adrenergic system and does not compromise cardiac function. PHYSIOLOGICAL REPORTS, v. 4, n. 17, SEP 2016. (12/20725-7, 12/16647-0)