Advanced search
Start date

Collagen type I and III protein expression in the myocardial of obesity resistant rats induced by saturated high-fat diet

Grant number: 13/23954-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2014
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Antonio Carlos Cicogna
Grantee:Scarlet Marques de Oliveira
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Obesity is a chronic metabolic disorder characterized by excessive accumulation of adipose tissue in relation to lean tissue. Currently, it is a global epidemic and a major public health problem that affects both developed as well as developing countries. The heart is composed essentially of myocytes, vessels and interstitial collagen matrix. The types of collagen found in the heart are predominantly types I and III, whereas the type I accounts for approximately 80% of myocardial total collagen. The collagen in stable condition, contributes to the maintenance of architecture and cardiac function. However, in response to stimulus caused by mechanical or neurohormonal agents, collagen may change, affecting the movement myofibril. In animal experiments, rats submitted high-fat diet often develop obesity, but even maintaining the same conditions, some animals do not become obese and are called obesity resistant rats. Due to the absence of studies of myocardial collagen I and III in obesity resistant rats by high-fat diet rich in saturated fatty acids, the purpose of this study is to quantify the fractions of myocardial collagen I and III in obesity resistant rats treated for 30 weeks saturated fat diet.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items