EXPRESSION OF MYOCARDIAL CALCIUM HANDLING PROTEINS IN OBESE RATS BY SATURATED HIGH-FAT DIET

• Grant number: 12/20733-0
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): September 01, 2013
• Effective date (End): February 28, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio Carlos Cicogna
• Grantee: Adriana Fernandes de Deus
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Obesity is a current problem that occurs in developed and undeveloped countries, in different age groups and social classes. Several factors may lead to obesity: genetic, psychological, physical inactivity and inappropriate dietary habits. Considered a chronic metabolic disorder characterized by excessive fat accumulation in relation to lean tissue, is associated with increased risk of mortality, reduced life expectancy and numerous comorbidities such as type II diabetes, insulin resistance, dyslipidemia and cardiovascular diseases. Several structural, hemodynamic and functional changes of the heart, in humans and animals, have been frequently associated with obesity. Although the increase in adipose tissue may cause changes in cardiac function, the mechanisms responsible for these changes are unclear. Different factors, such as alterations in the calcium handling proteins, have been suggested as responsible for the possible cardiac functional abnormalities in animal models of obesity. The literature stated that obesity by unsaturated high-fat diet does not promote changes in the expression of proteins related to the myocardial calcium handling. It is well established the association of saturated fatty acids and increased cardiovascular disease risk, in addition, saturated fatty acids can lead to myocardial alterations such as apoptosis, hypertrophy and increased nuclear volume. There are no studies that evaluated the calcium handling proteins in the obesity by saturated high-fat diet. The aim of this study is to test the hypothesis that obesity induced by saturated high-fat diet leads to changes in the expression of proteins related to the myocardial calcium handling.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DEUS, A. F.; VILEIGAS, D. F.; SILVA, D. C. T.; TOMASI, L. C.; CAMPOS, D. H. S.; OKOSHI, K.; PADOVANI, C. R.; CICOGNA, A. C.. Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity. Brazilian Journal of Medical and Biological Research, v. 52, n. 6, 2019. (12/20733-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DEUS, Adriana Fernandes de. Expressão das proteínas envolvidas no trânsito de cálcio miocárdico de ratos obesos por dieta hiperlipídica saturada. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.