Pharmacokinetics-pharmacodynamics evaluation of poloxamer-based tramadol formulations

• Grant number: 12/16822-7
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2013
• End date: July 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology - Clinical Pharmacology
• Principal Investigator: Giovana Tofoli Moniz
• Grantee: Giovana Tofoli Moniz
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

In the last decades the development of drug-delivery systems, such as thermoreversible gels made it possible to manipulate some biopharmaceutical and pharmacological properties of drugs, improving their therapeutic effects (long duration of action associated to low systemic toxicity) and their clinical use. Opioids, such as tramadol, are widely used in clinical medicine for sedation or analgesia. However, these drugs can induce typical opioid side-effects, such as constipation, respiratory depression, nausea, vomiting, dependence and tolerance, even with the use of small dosages applied by different routes of administration. The use of poloxamers to form thermoreversible gels, would be interesting due to its capacity of improve the pharmacological properties of this opioid and the possibility of alterations in the posology of this drug, being potentially advantageous for the pain relief. Thus, the aims of this study is to correlate the pharmacokinetics and pharmacodynamics induced by tramadol associated with poloxamers in comparison with its aqueous formulation in rabbits, looking forward to its clinical use. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BOAVA PAPINI, JULIANA ZAMPOLI; SAIA CEREDA, CINTIA MARIA; PEDRAZZOLI JUNIOR, JOSE; CALAFATTI, SILVANA APARECIDA; DE ARAUJO, DANIELE RIBEIRO; TOFOLI, GIOVANA RADOMILLE. Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in Thermoreversible Gels. BIOMED RESEARCH INTERNATIONAL, 2017. (12/16822-7)

BOAVA PAPINI, JULIANA ZAMPOLI; SAIA CEREDA, CINTIA MARIA; PEDRAZZOLI JUNIOR, JOSE; CALAFATTI, SILVANA APARECIDA; DE ARAUJO, DANIELE RIBEIRO; TOFOLI, GIOVANA RADOMILLE. Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in Thermoreversible Gels. BIOMED RESEARCH INTERNATIONAL, v. 2017, p. 7-pg., 2017-01-01. (12/16822-7)