Evaluation of vaginal mucosa of women with premature ovarian failure and its relationship with lubrication, dyspareunia and sexual function

• Grant number: 12/07187-6
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2012
• End date: November 30, 2014
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Cristina Laguna Benetti Pinto
• Grantee: Cristina Laguna Benetti Pinto
• Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: POLIANA CORDEIRO CÉSAR PACELLO

Abstract

The relationship of premature ovarian failure with the presence or absence of sexual dysfunction in its psychological domains (desire, arousal, orgasm and satisfaction) and physical (lubrication and pain) is still not well studied and the impact on the lives of these women may compromise family and emotional dynamics. Objectives: To evaluate the vaginal mucosa of women with premature ovarian failure in use of oral hormone therapy and its relationship to sexual dysfunction in the lubrication and dyspareunia domains. Subjects and methods: There will be a pilot study with 36 women with premature ovarian failure and their age-matched controls. Women will be evaluated only once, and evaluation of sexual dysfunction will be conducted through the questionnaire Female Sexual Function Index. The vaginal trophism will be obtained through the vaginal pH, vaginal score and vaginal hormonal citology. Vaginal flora will be obtained by the test of amines, fresh bacterioscopy and stained by Gram and culture for fungus. Analysis: For each group it will be calculated the average age and lubrication and pain score. For the other variables will be calculated the percentage of each category in relation to groups. Statistical tests used are Chi-square, t test and Pearson's correlation index. The significance level is 5% and statistical analysis software SAS version 9.2 will be used. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PACELLO, P. C. C.; YELA, D. A.; RABELO, S.; GIRALDO, P. C.; BENETTI-PINTO, C. L.. Dyspareunia and lubrication in premature ovarian failure using hormonal therapy and vaginal health. CLIMACTERIC, v. 17, n. 4, p. 342-347, AUG 2014. (12/07187-6)