ADAM10 as a biomarker for Alzheimer's Disease: a study with Brazilian elderly

• Grant number: 12/22529-0
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Duration: December 01, 2012 - May 31, 2013
• Field of knowledge: Health Sciences - Nursing
• Principal Investigator: Márcia Regina Cominetti
• Grantee: Márcia Regina Cominetti
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Alzheimer's disease (AD) is the most common cause of dementia in people above age 65. Platelets studies with ADAM10 have shown that its expression is reduced in AD patients. The aim of this research was to compare the platelet levels of ADAM10 protein in two Brazilian elderly groups, considering the stages of the disease. The SDS-PAGE technique followed by western blotting was used. Data were analyzed using comparison, correlation and association statistical methods. The results showed reduced platelet ADAM10 levels in AD elderly compared to non-AD subjects. The disease progression intensified this reduction. ADAM10 was the only statistically significant variable (p = 0.01) to increase the AD occurrence probability. The cutoff value of < 0.4212 in ROC curve captured sensitivity and specificity of 70% and 80.77%, respectively. Together with other clinical criteria, ADAM10 seems to be a relevant biomarker tool for early and accurate AD diagnosis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MANZINE, PATRICIA REGINA; DE FRANCA BRAM, JESSYKA MARIA; BARHAM, ELISABETH JOAN; CARVALHO DO VALE, FRANCISCO DE ASSIS; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; COMINETTI, MARCIA REGINA; IOST PAVARINI, SOFIA CRISTINA. ADAM10 as a Biomarker for Alzheimer's Disease: A Study with Brazilian Elderly. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, v. 35, n. 1-2, p. 58-66, 2013. (10/09497-7, 12/22529-0)