Association between epicardial adipose tissue inflammation and coronary artery disease: a clinicopathological study

• Grant number: 13/00335-2
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2013
• End date: October 31, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Claudia Kimie Suemoto
• Grantee: Claudia Kimie Suemoto
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Carlos Augusto Gonçalves Pasqualucci ; Daniela Souza Farias Itao ; Luiz Fernando Ferraz da Silva ; Wilson Jacob Filho

Abstract

One of the main cause of morbidity and mortality in the world is coronary artery disease (CAD). Studies that investigate the pathophysiology of CAD are important to the prevention and treatment of this disease. The inflammation in epicardial adipose tissue (EAP) appears to be associated with CAD. However, the relation between the proximity of CAD and inflammation in EAP has not been elucidated in previous studies due to methodological limitations. Aim: To investigate the association between inflammation in EAP and coronary artery atherosclerosis in a clinicopathological study. Methods: This cross-sectional study will be performed at the São Paulo Autopsy Service. A sample of 78 cases will be collected. Coronary arteries (the main left coronary artery, circumflex, left anterior descending and right coronary) will be represented in the point of the highest obstruction. The samples will be divided in three groups: control, acute CAD, chronic CAD, according to obstruction degree and anatomopathologic classification of atherosclerosis. The sample of EAP near the coronary artery stenosis will be analyzed. Perirenal visceral adipose tissue and subcutaneous adipose tissue will be considered an external control to epicardial inflammation. The inflammatory cells (macrophages, lymphocytes B and T) will be quantified using immunochemistry. The quantity of inflammatory cells will be compared between three groups. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FARIAS-ITAO, DANIELA SOUZA; PASQUALUCCI, CARLOS AUGUSTO; NISHIZAWA, ALINE; FERRAZ SILVA, LUIZ FERNANDO; CAMPOS, FERNANDA MARINHO; SOUZA DA SILVA, KAREN CRISTINA; PARAIZO LEITE, RENATA ELAINE; GRINBERG, LEA TENENHOLZ; LUCENA FERRETTI-REBUSTINI, RENATA ELOAH; JACOB FILHO, WILSON; et al. Perivascular Adipose Tissue Inflammation and Coronary Artery Disease: An Autopsy Study Protocol. JMIR RESEARCH PROTOCOLS, v. 5, n. 4, OCT-DEC 2016. (13/00335-2)

FARIAS-ITAO, DANIELA SOUZA; PASQUALUCCI, CARLOS AUGUSTO; NISHIZAWA, ALINE; DA SILVA, LUIZ FERNANDO FERRAZ; CAMPOS, FERNANDA MARINHO; BITTENCOURT, MARCIO SOMMER; DA SILVA, KAREN CRISTINA SOUZA; LEITE, RENATA ELAINE PARAIZO; GRINBERG, LEA TENENHOLZ; FERRETTI-REBUSTINI, RENATA ELOAH DE LUCENA; et al. B Lymphocytes and Macrophages in the Perivascular Adipose Tissue Are Associated With Coronary Atherosclerosis: An Autopsy Study. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 8, n. 24, DEC 17 2019. (13/00335-2, 13/12290-3)

YAHAGI-ESTEVAM, MARISTELLA; FARIAS-ITAO, DANIELA SOUZA; PARAIZO LEIT, RENATA ELAINE; RODRIGUEZ, ROBERTA DIEHL; PASQUALUCCI, CARLOS AUGUSTO; NITRINI, RICARDO; JACOB-FILHO, WILSON; POWER, MELINDA C.; SUEMOTO, CLAUDIA KIMIE. The Potential Role of Selection Bias in the Association Between Coronary Atherosclerosis and Cognitive Impairment. JOURNAL OF ALZHEIMER'S DISEASE, v. 93, n. 4, p. 10-pg., 2023-01-01. (17/11313-0, 13/12290-3, 17/24066-1, 13/00335-2)

FARIAS-ITAO, DANIELA SOUZA; PASQUALUCCI, CARLOS AUGUSTO; DE ANDRADE, RENATO ARAUJO; FERRAZ DA SILVA, LUIZ FERNANDO; YAHAGI-ESTEVAM, MARISTELLA; GELAS LAGE, SILVIA HELENA; PARAIZO LEITE, RENATA ELAINE; CAMPO, ALEXANDRE BRINCALEPE; SUEMOTO, CLAUDIA KIMIE. Macrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosis. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 11, n. 6, p. 30-pg., 2022-03-15. (13/12290-3, 17/11313-0, 13/00335-2, 17/24066-1)