Study of endothelial dysfunction and hemostatic in patients with primary antiphospholipid syndrome

• Grant number: 13/02785-5
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2013
• End date: June 30, 2015
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Rosangela de Paula Silva Soares
• Grantee: Rosangela de Paula Silva Soares
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Endothelial dysfunction involving endothelial cells, platelets and leukocytes, is present in primary antiphospholipid syndrome (APS), associated with increased risk of thrombosis and shorter survival. Studies on microvascular dysfunction are scarce in primary APS. The present study plans: to characterize endothelial dysfunction manifests in patients with primary APS and correlate with antibody titers (lupus anticoagulant, anticardiolipin and anti ²2-glycoprotein) throught the measurement of biochemical markers; binding capacity of VWF to FVIII; investigate fibrinolytic activity and platelet activation in these patients. We also intend to register, patients included in the possible occurrence of bleeding episodes, tomographic findings consistent with the presence of venous or arterial thrombosis. We believe that better understanding of oral anticoagulation and changes related to endothelial dysfunction and thrombosis would have major implications for the choice of treatment, the decision to use anticoagulant therapy associated. Moreover, the study of these changes in APS patients could provide elements for understanding the link between endothelial injury and antiphospholipid antibody titer in the setting of coagulation and thrombosis in primary SAF. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NASCIMENTO, NATALIA MASTANTUONO; BYDLOWSKI, SERGIO PAULO; SILVA SOARES, ROSANGELA PAULA; OLIVEIRA DE ANDRADE, DANIELI CASTRO; BONFA, ELOISA; COSTA SEGURO, LUCIANA PARENTE; BORBA, EDUARDO FERREIRA. ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, v. 40, n. 3, p. 374-378, OCT 2015. (13/02785-5)