Molecular diagnosis by detection of specific DNA in blood samples from rats experimentally infected with Strongyloides venezuelensis

• Grant number: 13/03304-0
• Support Opportunities: Regular Research Grants
• Duration: June 01, 2013 - May 31, 2015
• Field of knowledge: Biological Sciences - Parasitology - Helminthology of Parasites
• Principal Investigator: Fabiana Martins de Paula
• Grantee: Fabiana Martins de Paula
• Host Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Pedro Paulo Chieffi ; Ronaldo Cesar Borges Cryschek

Abstract

Strongyloidiasis is a parasitic disease caused by the nematode Strongyloides stercoralis. This helminthiasis is potentially severe in immunosuppressed patients. Increasingly has used the species S. venezuelensis as an alternative for the production of antigens, the study host-parasite interaction, therapeutic assays, as well as in studies involving molecular biology methods. To evaluate the application of blood samples in molecular diagnosis of strongyloidiasis will be used rats (Rattus norvegicus) experimentally infected with S. venezuelensis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BOSQUI, LARISSA RODRIGUES; CORRAL, MARCELO ANDREETTA; LEVY, DEBORA; BYDLOWSKI, SERGIO PAULO; BORGES GRYSCHEK, RONALDO CESAR; CUSTODIO, LUIZ ANTONIO; PAVANELLI, WANDER ROGERIO; CONCHON-COSTA, IVETE; COSTA-CRUZ, JULIA MARIA; DE PAULA, FABIANA MARTINS; et al. Evaluation of the Dot-ELISA as a diagnostic test for human strongyloidiasis based on the detection of IgA in saliva. Acta Tropica, v. 203, MAR 2020. (13/03304-0)

BOSQUI, LARISSA R.; MARQUES, PRISCILLA D.; DE MELO, GESSICA B.; GONCALVES-PIRES, MARIA DO ROSARIO F.; MALTA, FERNANDA M.; PAVANELLI, WANDER R.; CONCHON-COSTA, IVETE; COSTA-CRUZ, JULIA M.; PAULA, FABIANA M.; COSTA, IDESSANIA N.. Molecular and Immnune Diagnosis: Further Testing for Human Strongyloidiasis. MOLECULAR DIAGNOSIS & THERAPY, v. 22, n. 4, p. 485-491, AUG 2018. (13/03304-0)

MARQUES, P. D.; MALTA, F. M.; MEISEL, D. M. C. L.; CORRAL, M. A.; PINHO, J. R.; COSTA-CRUZ, J. M.; CHIEFFI, P. P.; GRYSCHEK, R. C. B.; PAULA, F. M.. Diagnosis of the strongyloid nematode Strongyloides venezuelensis in experimentally infected rats. JOURNAL OF HELMINTHOLOGY, v. 90, n. 4, p. 422-427, JUL 2016. (13/03304-0)