Estimation of the infinitesimal generator of ion channel dynamics

• Grant number: 05/02063-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2005
• End date: September 30, 2007
• Field of knowledge: Physical Sciences and Mathematics - Probability and Statistics - Applied Probability and Statistics
• Principal Investigator: Rafael Andres Rosales Mitrowsky
• Grantee: Rafael Andres Rosales Mitrowsky
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

This project is concerned with the estimation of hidden Markov models used to describe the dynamics of single ion channels. The state spacefor these models is partitioned in classes of indistinguishable states, known as aggregates. More precisely, the project aims the development of efficient MCMC techniques specially suited to the estimation of the infinitesimal generator of these processes. The methods will be applied to data arising from the activity of a single BK channel. The dynamic properties of these molecules have been studied to some extent by conventional means. BK channels play a important role in cellular secretion processes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSALES, RAFAEL A.; VARANDA, WAMBERTO A.. Allosteric Control of Gating Mechanisms Revisited: The Large Conductance Ca2+-Activated K+ Channel. BIOPHYSICAL JOURNAL, v. 96, n. 10, p. 3987-3996, MAY 20 2009. (05/02063-3, 06/50954-7)