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Relationship between body fat and inflammatory markers and adipocytokines in nondialyzed chronic kidney disease patients

Grant number: 05/02442-4
Support type:Regular Research Grants
Duration: December 01, 2005 - May 31, 2008
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Lilian Cuppari
Grantee:Lilian Cuppari
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Cardiovascular disease (CVD) is the main cause of mortality in chronic kidney disease patients (CKD). Besides traditional risk factors, chronic inflammation and possibly reduced protector factors seem to be involved in the development of CVD in this population. It is well established in the general population the role of body fat, especially of visceral fat, in the development of the metabolic syndrome with consequent increase in the cardiovascular risk. However, in the CKD patients there are few studies in this area and the results are conflicting. Moreover, the relationship of inflammatory markers with visceral fat had never been studied. Moreover, the relationship of inflammatory markers with visceral fat has never been studied. Thus the aim of this study is to analyze the relation of total body fat, visceral fat and lean body mass with inflammatory markers and adipocytokines in CKD patients not yet on dialysis. The sample will include 100 adult patients in stages 2 to 4 of CKD (glomerular filtration rate of 89 to 15 ml/min). The following anthropometric parameters will be obtained: body weight, height, body mass index, midarm muscle circumference, triceps and subscapular skinfold thicknesses and waist circumference. Body composition will be assessed by dual-energy X-ray absortiometry (DEXA) and abdominal fat (subcutaneous and visceral) by computerized tomography. Nutritional status will be evaluated by the method of Subjective Global Assessment (SGA). The following laboratorial parameters will be measured: serum and urinary urea and creatinina, fasting glucose and insulin, serum albumin, triglycerides, total cholesterol and fractions. Insulin sensibility will be determined by calculating the homeostatic model assessment (HOMA). Inflammation will be detected by measuring C-reactive protein. Additionally, serum concentration of proinflammatory cytokines such as IL-1, IL-6 and TNF-alpha will be measured by ELISA This method will also be employed to determine serum leptin and adiponectin. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAMIMURA, M. A.; CARRERO, J. J.; CANZIANI, M. E. F.; WATANABE, R.; LEMOS, M. M.; CUPPARI, L. Visceral obesity assessed by computed tomography predicts cardiovascular events in chronic kidney disease patients. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 23, n. 9, p. 891-897, SEP 2013. Web of Science Citations: 6.
AOQUI, C.; CUPPARI, L.; KAMIMURA, M. A.; CANZIANI, M. E. F. Increased visceral adiposity is associated with coronary artery calcification in male patients with chronic kidney disease. European Journal of Clinical Nutrition, v. 67, n. 6, p. 610-614, JUN 2013. Web of Science Citations: 11.
FIGUIREDO-DIAS, VILANI; CUPPARI, LILIAN; GARCIA-LOPES, MIRIAM GHEDINI; DE CARVALHO, ALUIZIO BARBOSA; DRAIBE, SERGIO ANTONIO; KAMIMURA, MARIA AYAKO. Risk Factors for Hypovitaminosis D in Nondialyzed Chronic Kidney Disease Patients. JOURNAL OF RENAL NUTRITION, v. 22, n. 1, p. 4-11, JAN 2012. Web of Science Citations: 22.
VELLUDO, CLAUDIA M. O.; KAMIMURA, MARIA A.; SANCHES, FABIANA M. R.; LEMOS, MARCELO M.; CANZIANI, MARIA EUGENIA F.; PUPIM, LARA B.; DRAIBE, SERGIO A.; CUPPARI, LILIAN. Prospective Evaluation of Waist Circumference and Visceral Adipose Tissue in Patients with Chronic Kidney Disease. AMERICAN JOURNAL OF NEPHROLOGY, v. 31, n. 2, p. 104-109, 2010. Web of Science Citations: 17.

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