Cochlear nonlinearity: effects on otoacoustic emissions, diferencial limen of intensity and temporal resolution

• Grant number: 05/02474-3
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2006
• End date: June 30, 2008
• Field of knowledge: Health Sciences - Speech Therapy
• Principal Investigator: Renata Mota Mamede Carvallo
• Grantee: Renata Mota Mamede Carvallo
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

In comfortable situation of listening, as in quiet environment, the normal sensibility for pure tones can depend on the activity of only a restricted number of the inner hair cells (IHC) and the respectively associated neural fibers. The otoacoustic emissions are resultants from somatory effect of IHC activity, and may be more sensitive to initial cochlear dysfunction. To verify the influence of auditory dysfunction over OAE analysis, additional information about the otoacoustic emissions threshold and the effect of cochlear compression, both estimated by the distortion product emissions (DPOAE) growth rate curves are required. Additionally, the behavior of the differential intensity threshold can contribute for a better comprehension of hearing disorders. The motivation for this study was derived from the interest to accumulate information about the influence of external hair cells (EHC) dysfunction upon the differential threshold of intensity, and the DPOAE growth rate curves in individuals with and without auditory complaint. Objective: To verify the functions of compression and no-linearity of the cochlear amplifier, correlating the differential threshold of intensity, the DPOAE growth rate curves, and the temporal resolution in individuals with and without auditory disorders. Methodology: the sample will be composed by 90 individuals with ages between 12 and 30 years, 45 men and 45 women, distributed in three groups with 30 participants (15 female and 15 male) Group 1- subjects with mild neurosensorial hearing loss; Group 2 - subjects without auditory complaint and thresholds not higher than 15 dB from 250 to 8000 Hz; Group 3 - subjects with diagnosis of auditory processing disorder and thresholds not higher than 25 dB from 250 to 8000 Hz. Procedures: the subjects will be submitted to tests for verification of the inclusion and exclusion criteria, after that will be submitted to: ultra-high audiometry with tonal stimuli between 9 and 20kHz... (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GANDOLFI SANCHES, SEISSE GABRIELA; SANCHEZ, TANIT GANZ; MAMEDE CARVALLO, RENATA MOTA. Influence of Cochlear Function on Auditory Temporal Resolution in Tinnitus Patients. AUDIOLOGY AND NEURO-OTOLOGY, v. 15, n. 5, p. 273-281, 2010. (05/02474-3)

SANCHES, SEISSE GABRIELA GANDOLFI; SAMELLI, ALESSANDRA GIANNELLA; NISHIYAMA, ANNE KELLIE; SANCHEZ, TANIT GANZ; CARVALLO, RENATA MOTA MAMEDE. Teste GIN (Gaps-in-Noise) em ouvintes normais com e sem zumbido. Pró-Fono Revista de Atualização Científica, v. 22, n. 3, p. 257-262, 2010. (05/02474-3)

BUZO, BYANKA CAGNACCI; MAMEDE CARVALLO, RENATA MOTA. Psychoacoustic analyses of cochlear mechanisms in tinnitus patients with normal auditory thresholds. INTERNATIONAL JOURNAL OF AUDIOLOGY, v. 53, n. 1, p. 40-47, JAN 2014. (05/02474-3)