The pathophysiology of congestive heart failure: from the organ to tile molecules

• Grant number: 09/54225-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: September 01, 2010
• End date: August 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Paulo Jose Ferreira Tucci
• Grantee: Paulo Jose Ferreira Tucci
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: José Antonio Silva Junior ; Marcello Fabiano de Franco ; Ruy Ribeiro de Campos Junior
• Associated scholarship(s): 13/13332-1 - Possible interaction between Angiotensin II and aldosterone in renovascular hypertension in Wistar rats, BP.DR; 12/15808-0 - Gene expression characterization of signal transduction pathways in the remote myocardium after infarction induced by left ventricular ablation and coronary artery occlusion in rats, BP.DR

Abstract

The project aims at investigating the relevant aspects involved in the pathophysiology of Congestive Heart Failure (CHF). Seven subprojects will be part of the CHF experimental model induced in rats after myocardial necrosis. As a whole, the project includes: three subprojects to investigate the effects of prolonged use of digitoxin after myocardial infarction. One of them will conduct functional, structural, and molecular biology myocardial evaluation at pre-defined time points after coronary occlusion; the two others will evaluate how prolonged use of digitalis affects sympathetic nervous activity in two cerebral nuclei; three subprojects will investigate the effect of physical exercise in post myocardial infarction. One of them will evaluate the effect of physical exercise on the survival of infracted rats; a second one will keep a follow-up on the successive biochemical, genic, structural, and functional changes promoted by exercise in infracted rats; and the third one will evaluate the effect of physical exercise on late reperfusion repercussions over the structure, function and biochemical composition of the heart submitted to coronary occlusion; a subproject will be conducted in continuation to a previous research project, where the action of hyperbaric oxygen was proven to be beneficial after myocardial infarction. The subproject will analyze the action of hyperbaric oxygen on the myocardial oxidative stress of infracted rats. (AU)

Scientific publications

(20)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PICOLLO, CAMILA T.; DOS SANTOS, ALEXANDRA A.; ANTONIO, EDNEI L.; SILVA, JAIRO M. A.; BOCALINI, DANILO; SERRA, ANDREY JORGE; IHARA, SILVIA S. M.; TUCCI, PAULO J. F.. Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, NOV 2019. (09/54225-8)

VIEIRA, STELLA SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; NEVES DOS SANTOS, LUIS FELIPE; SANTANA, EDUARDO TADEU; FELICIANO, REGIANE; NAVARRO MARQUES, FABIO LUIZ; FARIA, DANIELE DE PAULA; BUCHPIGUEL, CARLOS ALBERTO; SILVA JR, JOSE ANTONIO; et al. Increased Myocardial Retention of Mesenchymal Stem Cells Post-MI by Pre-Conditioning Exercise Training. STEM CELL REVIEWS AND REPORTS, v. 16, n. 4, APR 2020. (09/54225-8, 18/06865-7, 15/11028-9)

FELICIANO, REGIANE DOS SANTOS; BARBOZA ATUM, ALLAN LUIS; DA SILVA RUIZ, ERICO GUSTAVO; SERRA, ANDREY JORGE; ANTONIO, EDNEI LUIZ; MANCHINI, MARTHA TRINDADE; AUGUSTO SILVA, JAIRO MONTEMOR; FERREIRA TUCCI, PAULO JOSE; NATHANSON, LUBOV; MORRIS, MARIANA; et al. Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling. Lasers in Surgery and Medicine, APR 2021. (12/15808-0, 09/54225-8, 15/11028-9)

BARBOZA ATUM, ALLAN LUIS; ALVES DA SILVA, JOSE ALMIR; MARQUES, DANILA; PRATES, RENATO ARAUJO; CONSOLIM-COLOMBO, FERNANDA MARCIANO; COSTA IRIGOYEN, MARIA CLAUDIA; DALBONI, MARIA APARECIDA; CHAVANTES, MARIA CRISTINA; SILVA JR, JOSE ANTONIO. Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin. Lasers in Medical Science, v. N/A, p. 9-pg., 2021-09-18. (09/54225-8)

SANTANA, EDUARDO T.; FELICIANO, REGIANE DOS SANTOS; SERRA, ANDREY J.; BRIGIDIO, EDUARDO; ANTONIO, EDNEI L.; TUCCI, PAULO J. F.; NATHANSON, LUBOV; MORRIS, MARIANA; SILVA, JR., JOSE A.. Comparative mRNA and MicroRNA Profiling during Acute Myocardial Infarction Induced by Coronary Occlusion and Ablation Radio-Frequency Currents. FRONTIERS IN PHYSIOLOGY, v. 7, NOV 25 2016. (15/11028-9, 12/15808-0, 09/54225-8)

SILVA, JR., JOSE ANTONIO; SANTANA, EDUARDO TADEU; MANCHINI, MARTHA TRINDADE; ANTONIO, EDNEI LUIS; BOCALINI, DANILO SALES; KRIEGER, JOSE EDUARDO; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis. PLoS One, v. 9, n. 3, MAR 10 2014. (09/54225-8)

DOS SANTOS, ALEXANDRA A.; HELBER, IZO; ANTONIO, EDNEI L.; FRANCO, MARCELO F.; TUCCI, PAULO J. F.. Severity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarction. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 167, n. 2, p. 357-361, JUL 31 2013. (09/54225-8)

VIEIRA, STELLA SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; NEVES DOS SANTOS, LUIS FELIPE; SANTANA, EDUARDO TADEU; FELICIANO, REGIANE; NAVARRO MARQUES, FABIO LUIZ; FARIA, DANIELE DE PAULA; BUCHPIGUEL, CARLOS ALBERTO; SILVA JR, JOSE ANTONIO; et al. Increased Myocardial Retention of Mesenchymal Stem Cells Post-MI by Pre-Conditioning Exercise Training. STEM CELL REVIEWS AND REPORTS, v. 16, n. 4, p. 12-pg., 2020-04-18. (18/06865-7, 09/54225-8, 15/11028-9)

FELICIANO, REGIANE SANTOS; MANCHINI, MARTHA T.; SANTANA, EDUARDO T.; MARETTI, JOAO V.; CAPRONI, LARISSA I.; ANTONIO, EDNEI; SERRA, ANDREY J.; TUCCI, PAULO J.; SILVA, JOSE A., JR.. Lasertherapy after induction of myocardial infarction by coronary artery occlusion in rats: a genetic signature. FASEB JOURNAL, v. 31, p. 1-pg., 2017-04-01. (12/15808-0, 15/11028-9, 09/54225-8)

PICOLLO, CAMILA T.; DOS SANTOS, ALEXANDRA A.; ANTONIO, EDNEI L.; SILVA, JAIRO M. A.; BOCALINI, DANILO; SERRA, ANDREY JORGE; IHARA, SILVIA S. M.; TUCCI, PAULO J. F.. Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, v. 25, n. 3, p. 8-pg., 2019-11-12. (09/54225-8)

LEVY, R. F.; SERRA, A. J.; ANTONIO, E. L.; DOS SANTOS, L.; BOCALINI, D. S.; PESQUERO, J. B.; BADER, M.; MERINO, V. F.; DE OLIVEIRA, H. A.; DE ARRUDA VEIGA, E. C.; et al. Cardiac Morphofunctional Characteristics of Transgenic Rats With Overexpression of the Bradykinin B1 Receptor in the Endothelium. Physiological Research, v. 66, n. 6, p. 925-932, 2017. (09/54225-8, 15/11028-9)

OLIVEIRA, MARIO S.; TANAKA, LEONARDO Y.; ANTONIO, EDNEI L.; BRANDIZZI, I, LAURA; SERRA, ANDREY J.; DOS SANTOS, LEONARDO; KRIEGER, JOSE E.; LAURINDO, FRANCISCO R. M.; TUCCI, PAULO J. F.. Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model. MOLECULAR MEDICINE REPORTS, v. 21, n. 3, p. 1431-1438, MAR 2020. (09/54225-8)

FELICIANO, REGIANE DOS SANTOS; BARBOZA ATUM, ALLAN LUIS; DA SILVA RUIZ, ERICO GUSTAVO; SERRA, ANDREY JORGE; ANTONIO, EDNEI LUIZ; MANCHINI, MARTHA TRINDADE; AUGUSTO SILVA, JAIRO MONTEMOR; FERREIRA TUCCI, PAULO JOSE; NATHANSON, LUBOV; MORRIS, MARIANA; et al. Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling. Lasers in Surgery and Medicine, v. 53, n. 9, p. 1247-1257, NOV 2021. (09/54225-8, 12/15808-0, 15/11028-9)

SALLES, THIAGO DE ALMEIDA; ZOGBI, CAMILA; DE LIMA, THAIS MARTINS; CARNEIRO, CAMILA DE GODOI; GARCEZ, ALEXANDRE TELES; BARBEIRO, HERMES VIEIRA; ANTONIO, EDNEI LUIZ; DOS SANTOS, LEONARDO; PEREIRA, ALEXANDRE DA COSTA; FERREIRA TUCCI, PAULO JOSE; et al. The contributions of dipeptidyl peptidase IV to inflammation in heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 310, n. 11, p. H1760-H1772, JUN 1 2016. (11/07402-1, 13/10619-8, 09/54225-8)

FARDIN, NUBIA MANTOVAN; ANTONIO, EDNEI LUIZ; SILVA MONTEMOR, JAIRO AUGUSTO; DA VEIGA, GLAUCIA LUCIANO; FERREIRA TUCCI, PAULO JOSE; CAMPOS, RUY R.. Digitoxin improves cardiovascular autonomic control in rats with heart failure. Canadian Journal of Physiology and Pharmacology, v. 94, n. 6, p. 643-650, JUN 2016. (09/54225-8)

MANCHINI, MARTHA TRINDADE; SERRA, ANDREY JORGE; FELICIANO, REGIANE DOS SANTOS; SANTANA, EDUARDO TADEU; ANTONIO, EDNEI LUIS; CAMILLO DE CARVALHO, PAULO DE TARSO; MONTEMOR, JAIRO; CRAJOINAS, RENATO OLIVEIRA; COSTA GIRARDI, ADRIANA CASTELLO; FERREIRA TUCCI, PAULO JOSE; et al. Amelioration of Cardiac Function and Activation of Anti-Inflammatory Vasoactive Peptides Expression in the Rat Myocardium by Low Level Laser Therapy. PLoS One, v. 9, n. 7, JUL 3 2014. (09/54225-8)

DOS SANTOS, LEONARDO; SALLES, THIAGO A.; ARRUDA-JUNIOR, DANIEL F.; CAMPOS, LUCIENE C. G.; PEREIRA, ALEXANDRE C.; BARRETO, ANA LUIZA T.; ANTONIO, EDNEI L.; MANSUR, ALFREDO J.; TUCCI, PAULO J. F.; KRIEGER, JOSE E.; et al. Circulating Dipeptidyl Peptidase IV Activity Correlates With Cardiac Dysfunction in Human and Experimental Heart Failure. Circulation-Heart Failure, v. 6, n. 5, p. 1029-1038, SEP 2013. (12/10146-0, 09/54225-8)

ANTONIO, EDNEI LUIZ; SERRA, ANDREY JORGE; DOS SANTOS, ALEXANDRA ALBERTA; VIEIRA, STELLA SOUSA; AUGUSTO SILVA, JAIRO MONTEMOR; YOSHIZAKI, AMANDA; SOFIA, RENATO RODRIGUES; FERREIRA TUCCI, PAULO JOSE. Há diferenças entre os gêneros no remodelamento ventricular esquerdo após infarto do miocárdio em ratos?. Revista Brasileira de Cirurgia Cardiovascular, v. 30, n. 1, p. 70-76, JAN-FEB 2015. (09/54225-8)

AMADIO, ELIANE MARTINS; SERRA, ANDREY JORGE; GUARALDO, SIMONE A.; SILVA, JR., JOSE ANTNIO; ANTONIO, EDNEI LUIS; SILVA, FLAVIO; PORTES, LESLIE ANDREWS; FERREIRA TUCCI, PAULO JOSE; PINTO LEAL-JUNIOR, ERNESTO CESAR; CAMILLO DE CARVALHO, PAULO DE TARSO. The action of pre-exercise low-level laser therapy (LLLT) on the expression of IL-6 and TNF-alpha proteins and on the functional fitness of elderly rats subjected to aerobic training. Lasers in Medical Science, v. 30, n. 3, p. 1127-1134, APR 2015. (09/54225-8)

REIS JUNIOR, DERMEVAL; ANTONIO, EDNEI LUIZ; DE FRANCO, MARCELLO FABIANO; DE OLIVEIRA, HELENITA ANTONIA; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Association of Exercise Training with Tobacco Smoking Prevents Fibrosis but has Adverse Impact on Myocardial Mechanics. NICOTINE & TOBACCO RESEARCH, v. 18, n. 12, p. 2268-2272, DEC 2016. (15/11028-9, 09/54225-8)