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Coupling of stress of endoplasmatic reticule with oxidative stress in vascular cells via interaction between protein disulfide isomerase and NAD(p)H oxidase: role of thiol oxidoredutases

Grant number: 04/13683-0
Support type:Research Projects - Thematic Grants
Duration: October 01, 2005 - March 31, 2010
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Francisco Rafael Martins Laurindo
Grantee:Francisco Rafael Martins Laurindo
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Co-Principal Investigators:Lucia Rossetti Lopes


The aim of this project is the development and implementation of Laser Induced Breakdown Spectroscopy (LIBS), an analytical technique based on sampling and excitation of atoms and molecules induced by laser. Most recently, LlBS has been considered a very promising analytical tool for in situ quantitative chemical analysis, either in industrial process as well as in the field. However, there is a lack of well-established methods when compared to the "super stars" of atomic spectrometry, namely GFAAS (Graphite Furnace Atomic Absorption Spectrometry), ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometry) and ICP-MS (Inductively Coupled Plasma Mass Spectrometry). The project will contribute to the development of fundamental studies in physics of plasmas induced by lasers from nanoseconds up to femtoseconds with peak powers of TeraWatt, as well as to the development and implementation of quantitative analytical methods for the determination of chemical species in materials of agronomic, environmental, industrial and forensic interest. All studies will be driven in collaboration with experimented scientific research groups in physics of laser appIication and analytical chemistry, and with the Environmental Protection Agency of São Paulo State (CETESB). The project also includes the development and evaluation of commercially available portable LlBS for in situ analysis of soils in collaboration with Brazilian Agricultural Research Corporation (Embrapa). (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BASSI, E.; LIBERMAN, M.; MARTINATTI, M. K.; BORTOLOTTO, L. A.; LAURINDO, F. R. M. Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis. Brazilian Journal of Medical and Biological Research, v. 47, n. 2, p. 119-127, Fev. 2014. Web of Science Citations: 3.
AMANSO, ANGELICA M.; DEBBAS, VICTOR; LAURINDO, FRANCISCO R. M. Proteasome Inhibition Represses Unfolded Protein Response and Nox4, Sensitizing Vascular Cells to Endoplasmic Reticulum Stress-Induced Death. PLoS One, v. 6, n. 1 JAN 26 2011. Web of Science Citations: 25.
DE ANDRADE, C. R.; LEITE, P. F.; MONTEZANO, A. C.; CASOLARI, D. A.; YOGI, A.; TOSTES, R. C.; HADDAD, R.; EBERLIN, M. N.; LAURINDO, F. R. M.; DE SOUZA, H. P.; CORREA, F. M. A.; DE OLIVEIRA, A. M. Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia. British Journal of Pharmacology, v. 157, n. 4, p. 568-580, JUN 2009. Web of Science Citations: 11.

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