Implementation of pre-exposure prophylaxis (PrEP) to HIV: a design statement

• Grant number: 12/51743-0
• Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)
• Start date: July 01, 2013
• End date: June 30, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: CNPq - PPSUS
• Principal Investigator: Esper Georges Kallás
• Grantee: Esper Georges Kallás
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Initial results of clinical trials of pre-exposure prophylaxis (PrEP), in the form of an oral pill daily indicate that this strategy can be extremely useful for the change of scenery needed in the fight against HIV infection. The World Health Organization (WHO) states that PrEP can be prioritized for high-risk populations including men who have sex with men (MSM), intravenous drug users and sex workers, as well as all those at risk of transmission sexual transmission in areas with endemic or hyperendemic HIV. This study is a multicenter open-label continuation and to evaluate the use of a daily pill containing tenofovir and emtricitabine in combination, in preventing HIV transmission, and will be conducted in three centers of Brazilian research. shall be included in this study 400 volunteers. MSM and transgender women at risk for HIV infection, which will be followed by one year after inclusion. Primary Objectives: (1) Describe the acceptance of the offered daily PrEP and MSM transsexual women. (2) determine differences in the acceptance of PrEP daily according to socio-demographic characteristics, including race / ethnicity, age, education and risk practices. (3) Determine the difference in the duration of PrEP use in accordance with socio-demographic characteristics, including race / ethnicity, age, education and risk practices. (4) Describe the side effects and toxicity of PrEP among participants. (5) Describe patterns and correlations of adherence to PrEP among participants. (6 ) measure changes in sexual risk behavior among participants. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VILLELA, LARISSA M.; VELOSO, VALDILEA G.; HOAGLAND, BRENDA; FERNANDES, NILO M.; KALLAS, ESPER G.; MADRUGA, V, JOSE; MOREIRA, I, RONALDO; GRINSZTEJN, BEATRIZ; DE BONI, RAQUEL B.. Possible risk compensation, attitudes, and beliefs among Brazilian individuals potentially eligible for pre-exposure prophylaxis. INTERNATIONAL JOURNAL OF STD & AIDS, v. 32, n. 9, p. 806-815, AUG 2021. (12/51743-0)

MONTEIRO SPINDOLA MARINS, LUANA; SILVA TORRES, THIAGO; LUZ, PAULA MENDES; MOREIRA, I, RONALDO; LEITE, IURI C.; HOAGLAND, BRENDA; KALLAS, ESPER G.; MADRUGA, V, JOSE; GRINSZTEJN, BEATRIZ; VELOSO, VALDILEA GONCALVES; et al. Factors associated with self-reported adherence to daily oral pre-exposure prophylaxis among men who have sex with man and transgender women: PrEP Brasil study. INTERNATIONAL JOURNAL OF STD & AIDS, v. 32, n. 13, JUL 2021. (12/51743-0)

VIEIRA, VINICIUS A.; AVELINO-SILVA, VIVIAN I.; CERQUEIRA, NATALIA B.; COSTA, DAYANE A.; COSTA, PRISCILLA R.; VASCONCELOS, RICARDO P.; MADRUGA, VALDEZ R.; MOREIRA, RONALDO I.; HOAGLAND, BRENDA; VELOSO, VALDILEA G.; et al. Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8(+) T-cell activation. AIDS, v. 31, n. 15, p. 2069-2076, SEP 24 2017. (12/51743-0)

HOAGLAND, BRENDA; MOREIRA, RONALDO I.; DE BONI, RAQUEL B.; KALLAS, ESPER G.; MADRUGA, JOSE VALDEZ; VASCONCELOS, RICARDO; GOULART, SILVIA; TORRES, THIAGO S.; MARINS, LUANA M. S.; ANDERSON, PETER L.; et al. High pre-exposure prophylaxis uptake and early adherence among men who have sex with men and transgender women at risk for HIV Infection: the PrEP Brasil demonstration project. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, v. 20, APR 6 2017. (12/51743-0)

MARINS, LUANA M. S.; TORRES, THIAGO S.; LEITE, IURI DA C.; MOREIRA, RONALDO I.; LUZ, PAULA M.; HOAGLAND, BRENDA; KALLAS, ESPER G.; MADRUGA, JOSE VALDEZ; LIU, ALBERT Y.; ANDERSON, PETER L.; et al. Performance of HIV pre-exposure prophylaxis indirect adherence measures among men who have sex with men and transgender women: Results from the PrEP Brasil Study. PLoS One, v. 14, n. 8, AUG 20 2019. (12/51743-0)