Evaluation of the occurrence and of estrogenic activity in endocrine disruptors in drinking water samples and of animals in different watersheds in the State of São Paulo. The E-screen assay validation: MCF7 cell culture bioassay

• Grant number: 12/25029-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2013
• End date: August 31, 2014
• Field of knowledge: Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
• Principal Investigator: Ana Maria Cristina Rebello Pinto da Fonseca Martins
• Grantee: Ana Maria Cristina Rebello Pinto da Fonseca Martins
• Host Institution: Instituto Biológico (IB). Agência Paulista de Tecnologia dos Agronegócios (APTA). Secretaria de Agricultura e Abastecimento (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Maria Lucia Zaidan Dagli

Abstract

Natural and synthetic estrogens have been detected in rivers, lakes and estuaries in many parts of the world. The primary sources of these compounds are domestic and industrial effluents, which are not deleted after the water treatment. Estrogen has been most searched for being very active biologically and be the Etiologic Agent of different types of cancer and other diseases such as endometriosis, premature puberty, feminization, masculinization, sterility. In this context we intend to use our water natural reservoirs or dams in a bioassay to try to characterize its estrogenicity in MCF7 cells culture and also to assess the most critical regions of São Paulo State (AU)