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Antimicrobial Brazilian propolis (EPP-AF) containing biocellulose membranes as promising biomaterrials for skin wound healing

Grant number: 13/14531-8
Support type:Regular Research Grants - Publications - Scientific article
Duration: August 01, 2013 - January 31, 2014
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Sidney José Lima Ribeiro
Grantee:Sidney José Lima Ribeiro
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Among remarkable discoveries concerning propolis, such as antifungal, antiviral, and antioxidant activities, its anti-inflamatory, and mainly its antibacterial properties deserve special attention when skin wound healing is concerned. Based on this and knowing the distinctive performance of bacterial (BC) membranes on wound healing, in this work it is proposed to demonstrate teh potent antimicrobial activity and wound healing properties of a novel propolis containing biocellulose membrane. The obtained propolis/BC membrane was able to adsorb propolis not only on the surface, but also in its interstices demonstrated by scanning electron microscopy, X-rays diffraction, Fourier Transform Infrared (FT-IR) spectroscopy and thermogravidimetric assays. Additionally, the polyphenolic compounds determination and the prominent antibacterial activity in the membrane are demonstrated to be dose dependent, supporting the possibility of obtaining propolis/BC membranes at the desired concentration, taking into consideration its application and itds skin residence time. Finally it could be suggested that propolis/BC membrane may favor tissue rapir in less time and more effectively in contaminated wounds (AU)