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Evaluation of the wound healing process in cronic ulcers using pure or propolis bacterial cellulose membranes curatives associated or not to lasertherapy

Grant number: 10/12369-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2011
Effective date (End): August 31, 2012
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Ana Maria Minarelli Gaspar
Grantee:Fernanda Sanchez
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Chronic wounds are a major source of morbidity-mortality; therefore, they have a significant impact on public health and the expenditure of healthcare resources. Some authors describe the presence of intrinsic (friction, pressure) and extrinsic factors (stillness, bad skin perfusion) to the pressure ulcers (PU) development. Bacterial cellulose (BC) membrane is used for treatment of burn injury or skin ulcers due to its amazing body conformation, keeping the humidity, reducing the pain and accelerating the healing process. The antibacterial effects of propolis and low-level laser therapy (LLLT) are confirmed, and LLLT also promoves the ulcer healing, pain relief, better local circulation and reducing inflammation. Objective: Compare the effectiveness of pure or propolis BC membrane curative application, associated or not to LLLT in individuals who have PU. Methods: 50 patients will participate of this study, and they will be divided in 5 groups: Pure BC Membrane Group, Propolis BC Membrane Group, Laser Group, Pure BC Membrane + Laser Group, Propolis BC Membrane + Laser Group. BC membrane will be exchanged every week until the moment of the cure, or no later than 90 days. Laser applications will be made twice a week until the moment of the cure, or no later than 90 days. Pacients will be divided between groups randomly. Ulcers assessments will be carried with regards to its aspects, diameter and depth, thru a digital caliper rule and a camera. Expected results: Is expected that the association between pure or propolis BC and LLLT increases the regenerative effects of the injured tissue.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANCHEZ, Fernanda. Evaluation of the tecidual healing process in chronic ulcers using bacterial cellulose curatives associated or not to lasertherapy. 2012. Master's Dissertation - Universidade de São Paulo (USP). Escola de Engenharia de São Carlos (EESC/SBD) São Carlos.

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