Green tea effects on teeth sockets healing of rats treated with bisphosphonate

• Grant number: 13/04714-8
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2013
• End date: August 31, 2015
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Mariza Akemi Matsumoto
• Grantee: Mariza Akemi Matsumoto
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Disturbances in bone metabolism can result in a decrease in bone density leading to osteoporosis. In this way, the use of bisphosphonates (BF), and phytotherapic alternatives as the ingestion of green tea in order to inhibit osteoclastic activity and recover bone mass are indicated. Due to the popularity of green tea known by its anti-oxidant effects, added to the high number of individuals who use BFs, the aim of the present study is to analyze the effect of green tea at 1% on socket healing of animals treated with BFs. A total of 60 male Wistar rats will be distributed into three groups according to the treatment: Group C - Control, animals treated with endovenous (EV) 0.9% saline solution, Group CV - treated with green tea at 1% in drinking water, Group ZL - treated with EV zoledronic acid, Group ZL+CV - treated with EV zoledronic acid and green tea at 1% in drinking water. A dose of 0.035 mg/Kg of the BF will be administered every two weeks. After four weeks from the beginning of the BF administration, the animals will be submitted to right upper molars extractions, when 1% green tea will be offered to the animals of CV and ZL+CV groups. After 7, 14, and 28 days from teeth extractions, the animals will be euthanized with anesthetics overdose for the retrieval of the specimens to be prepared and analyzed considering morphological microscopy and immunohistochemistry. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MADA, EDSON YOSHIHIRO; CUNHA SANTOS, ALANA CLARO; FONSECA, ANGELICA CRISTINA; BIGUETTI, CLAUDIA CRISTINA; ALVES NEVES, FERNANDO TOZZE; SARAIVA, PATRICIA PINTO; MATSUMOTO, MARIZA AKEMI. Effects of green tea and bisphosphonate association on dental socket repair of rats. ARCHIVES OF ORAL BIOLOGY, v. 75, p. 1-7, MAR 2017. (13/04714-8)

BIGUETTI, CLAUDIA CRISTINA; RONDINA COUTO, MAIRA CRISTINA; RODRIGUES SILVA, ANA CLAUDIA; TADASHI COSIN SHINDO, JOAO VITOR; ROSA, VINICIUS MATEUS; SHINOHARA, ANDRE LUIS; ANDREO, JESUS CARLOS; HUNGARO DUARTE, MARCO ANTONIO; WANG, ZHIYING; BROTTO, MARCO; et al. New Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse. FRONTIERS IN ENDOCRINOLOGY, v. 11, AUG 11 2020. (18/19406-0, 13/04714-8, 18/08913-9)

BIGUETTI, CLAUDIA CRISTINA; DE OLIVA, ANDRE PRIME HERGESEL; HEALY, KENT; MAHMOUD, RAMEZ HASSAN; CUSTODIO, ISABELA DO CARMO; CONSTANTINO, DULCE HELENA; ERVOLINO, EDILSON; HUNGARO DUARTE, MARCO ANTONIO; FAKHOURI, WALID D.; MATSUMOTO, MARIZA AKEMI. Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: Microtomographic, histological and immunohistochemical characterization. PLoS One, v. 14, n. 6, JUN 14 2019. (13/04714-8, 18/19409-0)