Role of perivascular adipose tissue in aorta and femoral arteries from trained mice fed with high-fat diet

• Grant number: 13/02960-1
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2013
• End date: August 31, 2015
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Maria Andréia Delbin
• Grantee: Maria Andréia Delbin
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Sedentary lifestyle associated with adiposity are considered important factors in the genesis of cardiovascular disease. The role of perivascular adipose tissue in vascular function has recently been recognized. In this study we aim to investigate the role of perivascular adipose tissue in the vascular responsiveness of aorta and femoral arteries in trained mice fed with high-fat diet. Concentration-response curves to: leptin, adiponectin, acetylcholine, sodium nitroprusside, phenylephrine, thromboxane A2 analog and endothelin-1 will be obtained with and without perivascular adipose tissue (PVAT+/PVAT-). Vascular and PVAT protein expression of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), cytosolic Cu/Zn-superoxide dismutase (SOD-1), mitochondrial Mn-superoxide dismutase (SOD-2), extracellular superoxide dismutase (EC-SOD) and tumor necrosis factor alpha (TNF-±) will be determine. Tissues nitric oxide (NO) production and reactive oxygen species (ROS) generation will be evaluate in PVAT+/PVAT-. Plasma glucose, total cholesterol, triglycerides, TNF-±, IL-10, adiponectin, leptin, resistin, nitrite/nitrate and thiobarbituric acid reactive substances (TBARS) will be analyzed. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARAUJO, HYGOR N.; VICTORIO, JAMAIRA A.; VALGAS DA SILVA, CARMEM P.; SPONTON, AMANDA C. S.; VETTORAZZI, JEAN F.; DE MORAES, CAMILA; DAVEL, ANA P.; ZANESCO, ANGELINA; DELBIN, MARIA A.. Anti-contractile effects of perivascular adipose tissue in thoracic aorta from rats fed a high-fat diet: role of aerobic exercise training. Clinical and Experimental Pharmacology and Physiology, v. 45, n. 3, p. 10-pg., 2018-03-01. (13/02960-1)

SOUSA, ANDRESSA S.; SPONTON, AMANDA C. S.; TRIFONE, CESAR B.; DELBIN, MARIA A.. Aerobic Exercise Training Prevents Perivascular Adipose Tissue-Induced Endothelial Dysfunction in Thoracic Aorta of Obese Mice. FRONTIERS IN PHYSIOLOGY, v. 10, AUG 16 2019. (13/02960-1)

ARAUJO, HYGOR N.; VICTORIO, JAMAIRA A.; VALGAS DA SILVA, CARMEM P.; SPONTON, AMANDA C. S.; VETTORAZZI, JEAN F.; DE MORAES, CAMILA; DAVEL, ANA P.; ZANESCO, ANGELINA; DELBIN, MARIA A.. Anti-contractile effects of perivascular adipose tissue in thoracic aorta from rats fed a high-fat diet: role of aerobic exercise training. Clinical and experimental pharmacology & physiology, v. 45, n. 3, p. 293-302, MAR 2018. (13/02960-1)

SOUSA, ANDRESSA S.; SPONTON, AMANDA C. S.; DELBIN, MARIA A.. Perivascular adipose tissue and microvascular endothelial dysfunction in obese mice: Beneficial effects of aerobic exercise in adiponectin receptor (AdipoR1) and peNOS(Ser1177). Clinical and Experimental Pharmacology and Physiology, v. 48, n. 10, JUL 2021. (13/02960-1)

ANARUMA, CHADI P.; FERREIRA, JR., MAYCON; SPONTON, CARLOS H. G.; DELBIN, MARIA A.; ZANESCO, ANGELINA. Heart rate variability and plasma biomarkers in patients with type 1 diabetes mellitus: Effect of a bout of aerobic exercise. Diabetes Research and Clinical Practice, v. 111, p. 19-27, JAN 2016. (13/02960-1, 11/17437-7)