| Grant number: | 12/19362-7 |
| Support Opportunities: | Regular Research Grants |
| Start date: | September 01, 2013 |
| End date: | April 30, 2016 |
| Field of knowledge: | Health Sciences - Medicine - Maternal and Child Health |
| Principal Investigator: | Marilza Vieira Cunha Rudge |
| Grantee: | Marilza Vieira Cunha Rudge |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| City of the host institution: | Botucatu |
| Associated researchers: | Daisy Maria Favero Salvadori ; Débora Cristina Damasceno ; Iracema de Mattos Paranhos Calderon ; João Paulo de Castro Marcondes |
Abstract
The concept of "fetal programming" has received special attention because it may interfere with factors related to the genesis and development of diseases in childhood, adolescence and adulthood. On the other hand, since literature shows that children from mothers with gestational diabetes mellitus (GDM) are at increased risk for developing obesity, becomes of great importance to characterize this stressor and to determine the mechanism(s) by which hyperglycemia acts. In this context, the objectives of the present study are to genetically classify women with Diabetes Mellitus (Gestational and type 2) and Mild Gestational Hyperglycemia (MGH) and to elucidate some of the mechanisms by which this disorder may predispose fetus/newborn to obesity. The project consists of two subprojects (Subprojects 1 and 2) that are complementary. Subproject 1 aims the characterization (gene expression profiling) of pregnant women with diabetes and mild hyperglycemia; Subproject 2 aims to identify in the fetus/newborn the toxicogenomics events induced by these metabolic disorders might which favor the development of obesity. The casuistic of the Subproject 1 include: Group1) Non-diabetic pregnant women (normal GTT and glycemic profile); Group 2) Pregnant women with MGH (normal TTG and altered glycemic profile); Group 3) Pregnant women with GDM (altered TTG and normal/altered glycemic profile); Group 4) Pregnant women with gestational and overt diabetes (altered TTG and glycemic profile). In the Subproject 2 will be included pregnant women with GDM (Group 1) and their respective newborns (Group 2), healthy pregnant women (Group 3) and their newborns (Group 4), and obese (Group 5) and eutrophic (Group 6) adults. The end-points to be assessed in blood cells and placenta are: gene expression profiling (microarrays) (Subprojects 1 and 2), microRNAs expression (Subproject 2) and gene methylation (Subproject 2). It is expected the genetic characterization of pregnant women with diabetes and MHG, and the identification of genetic and epigenetic changes in newborn cells allow to better understanding the relationship between hyperglycemia during pregnancy and obesity, and also to contribute to the establishment of strategies for preventing or reducing the risk of developing this metabolic disorder. (AU)
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