PD1, apoptosis and arginase in canine visceral leishmaniasis

• Grant number: 13/06684-9
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2013
• End date: October 31, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Valéria Marçal Felix de Lima
• Grantee: Valéria Marçal Felix de Lima
• Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The Visceral Leishmaniasis (VL) is a chronic and often fatal disease and it is increasing in number in the state of São Paulo, in urban areas as Araçatuba city. According to the Secretary of Epidemiological Surveillance of São Paulo State, the disease is expanding with a high mortality rate, and the Araçatuba region has the largest number of cases in the state. The canine VL is a serious public health problem because infected animals are powerful transmitters of the parasite to humans through the vector, and canine disease is more prevalent than the human disease, canine cases usually precede human cases. The dog is therefore a major target in control measures. The progression of canine disease is accompanied by failure in cellular immunity with reduced circulating lymphocytes and cytokines that suppress the function of macrophages, suppression of T cells is well documented, but the mechanisms that lead to failure in the immune response are poorly understood. Just want to check on the dogs naturally infected if the failure of cellular immunity and increased parasite load may be due to the expression of molecules negative costimulatory and increased arginase 1 in the spleen. The expression of PD1 and their ligands will be evaluated together with the activity of the enzyme arginase 1 and will be quantified parasite burden. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REBECH, GABRIELA TORRES; VENTURIN, GABRIELA LOVIZUTTO; SIQUEIRA ITO, LUCAS TAKESHI; BRAGATO, JAQUELINE POLETO; DE CARVALHO FONSECA, BIANCA STEFANINI; MELO, LARRISSA MARTINS; COSTA, SIDNEI FERRO; EUGENIO, FLAVIA DE REZENDE; PATTO DOS SANTOS, PAULO SERGIO; FELIX DE LIMA, VALERIA MARCAL. PD-1 regulates leishmanicidal activity and IL-17 in dogs with leishmaniasis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 219, JAN 2020. (13/06684-9)

CHIKU, VANESSA MARIM; OLIVEIRA SILVA, KATHLENN LIEZBETH; MARTINS DE ALMEIDA, BRENO FERNANDO; VENTURIN, GABRIELA LOVIZUTTO; CORREA LEAL, ALINE APARECIDA; DE MARTINI, CLEBER COSTA; EUGENIO, FLAVIA DE REZENDE; PATTO DOS SANTOS, PAULO SERGIO; FELIX DE LIMA, VALERIA MARCAL. PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis. Immunobiology, v. 221, n. 8, p. 879-888, AUG 2016. (13/19399-0, 13/06684-9)

OLIVEIRA SILVA, KATHLENN LIEZBETH; CHIKU, VANESSA MARIN; VENTURIN, GABRIELA LUVIZOTTO; CORREA LEAL, ALINE APARECIDA; DE ALMEIDA, BRENO FERNANDO; EUGENIO, FLAVIA DE REZENDE; PATTO DOS SANTOS, PAULO SERGIO; MACHADO, GISELE FABRINO; FELIX DE LIMA, VALERIA MARCAL. PD-1 and PD-L1 regulate cellular immunity in canine visceral leishmaniasis. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, v. 62, p. 76-87, FEB 2019. (13/06684-9)

DE MARTINI, CLEBER COSTA; DE ANDRADE, JESSICA THOME; MARTINIANO DE ALMEIDA, STEFANI KARIN; OLIVEIRA SILVA, KATHLENN LIEZBETH; EUGENIO, FLAVIA DE REZENDE; PATTO DOS SANTOS, PAULO SERGIO; FELIX DE LIMA, VALERIA MARCAL. Cellular apoptosis and nitric oxide production in PBMC and spleen from dogs with visceral leishmaniasis. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, v. 57, p. 1-7, APR 2018. (13/06684-9)

VENTURIN, G. L.; CHIKU, V. M.; SILVA, K. L. O.; DE ALMEIDA, B. F. M.; DE LIMA, V. M. F.. M1 polarization and the effect of PGE(2) on TNF-alpha production by lymph node cells from dogs with visceral leishmaniasis. PARASITE IMMUNOLOGY, v. 38, n. 11, p. 698-704, NOV 2016. (13/06684-9)