Genetic polymorphisms of matrix metalloproteinases in resistant hypertension

• Grant number: 12/23608-1
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2014
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Gabriel Forato Anhê
• Grantee: Gabriel Forato Anhê
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Vanessa Fontana

Abstract

Resistant hypertension (RH) is characterized by high blood pressure in spite of concurrent use of three antihypertensive agents of different classes, combined at optimal doses and including a diuretic. Indeed, RH includes patients with controlled blood pressure using four or more agents. Resistant hypertensive patients have an unfavorable prognostic and the morbidity and mortality occur in consequence of the high prevalence of target-organ damage in these patients, including left ventricular hypertrophy and arterial stiffness. Metalloproteinases (MMPs) are a family of enzymes that degrade extracellular matrix proteins and are involved in cardiovascular remodeling related to target-organ damage in cardiovascular diseases, including hypertension (HT). Several studies in experimental models and in humans showed increased levels of MMPs-2 and -9 in HT. Furthermore, increased levels of MMP-9 were described as predictors of cardiovascular mortality. MMP-9 has an important role in inflammatory pathways. However, there is no study in resistant hypertension showing the role of MMPs in target-organ damage in this group of patients. The aim of this study is to evaluate the association of the levels and activity of MMP-2 and -9 and their inhibitors, TIMP-1 and TIMP-2, and how the polymorphisms in these two enzymes (MMP-2 -1575G>A; MMP-2 -1306C>T; MMP-2 -735C>T; MMP-9 -1562C>T; MMP-9 R279Q e MMP-9 R668Q) affect the left ventricular hypertrophy, arterial stiffness of the RH and HT diseases, as the presence of obstructive sleep apnea and lack of blood pressure control. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREA, NATHALIA BATISTA; DE FARIA, ANA PAULA; RITTER, ALESSANDRA M. V.; SABBATINI, ANDREA RODRIGUES; ALMEIDA, AURELIO; BRUNELLI, VERIDIANA; CALHOUN, DAVID A.; MORENO, HEITOR; MODOLO, RODRIGO. A practical approach for measurement of antihypertensive medication adherence in patients with resistant hypertension. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, v. 10, n. 6, p. 510-516, JUN 2016. (12/23608-1)

RITTER, ALESSANDRA M. V.; DE FARIA, ANA PAULA; BARBARO, NATALIA R.; SABBATINI, ANDREA R.; CORREA, NADIALIA BATISTA; BRUNELLI, VERIDIANA; FATTORI, ANDRE; AMORIN, RIVADAVIO; MODOLO, RODRIGO; MORENO, HEITOR. The rs243866/243865 polymorphisms in MMP-2 gene and the relationship with BP control in obese resistant hypertensive subjects. Gene, v. 646, p. 129-135, MAR 10 2018. (12/23608-1)

VERSUTI RITTER, ALESSANDRA MILENI; DE FARIA, ANA PAULA; BARBARO, NATALIA; SABBATINI, ANDREA RODRIGUES; CORREA, NATHALIA BATISTA; BRUNELLI, VERIDIANA; AMORIM, RIVADAVIO; MODOLO, RODRIGO; MORENO, HEITOR. Crosstalk between obesity and MMP-9 in cardiac remodelling -a cross-sectional study in apparent treatment-resistant hypertension. BLOOD PRESSURE, v. 26, n. 2, p. 122-129, APR 2017. (12/23608-1)