Advanced search
Start date
Betweenand

Epileptogenesis in human epileptic tissue. Structural and electrophysiological characteristics of the human epileptogenic tissue obtained from surgeries for epilepsy treatment. Clinical, electrographical and pathological correlations

Abstract

Epilepsy is a frequent neurological disturbance which affects around 1 % of the population. Thirty to fourty per cent of patients present epileptic seizures which are considered refractory to antiepileptic drugs. The understanding of the epileptogenicity in this population would allow the development of new therapeutic modalities and adequate medical approach of this population. Mesial temporal sclerosis, cortical developmental malformations and indolent tumors of the nervous system are among the pathological findings more commonly seen in this group of epileptic patients. The objective of this research aims to elucidate the mechanisms of epileptogenicity in these lesions whose electrophysiological and morphological basis will be approached in three distinct steps. These permitted the differenciation of three subprojects: Subproject 1. electroclinical characterization of patients with refractory partial epilepsy due to lesions whose mechanisms of epileptogenicity are not yet well known as double pathology of the temporal lobe (mesial temporal sclerosis associated with other lesions) and the cortical developmental malformations and indolent tumors of the nervous system. Subproject 2. in vitro electrophysiological studies of the human epileptogenic tissue aiming at the investigation of the microphysiological basis involved in the epileptogenicy of mesial temporal sclerosis, cortical developmental malformations and indolent tumors of the nervous system. Subproject 3. anatomopathological characterization and molecular biology studies of the human epileptic tissue removed from these three types of lesions. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SCORZA, FULVIO ALEXANDRE; ABREU, ANA MARIA FONSECA; ALBUQUERQUE, MARLY DE; PACHECO, JULIO B. COTA; BREVIGLIERI, RENATO; SANDER, JOSEMIR WANDERLEY; SILVA, ANTÔNIO CARLOS DA; CAVALHEIRO, ESPER ABRÃO; ARIDA, RICARDO MARIO. Quantification of respiratory parameters in patients with temporal lobe epilepsy. Arquivos de Neuro-Psiquiatria, v. 65, n. 2B, p. 450-453, June 2007.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.