Influence of actives / bioactive compounds on physicochemical and in vitro and in vivo functional parameters of lip molded sunscreens

• Grant number: 13/18689-5
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2014
• End date: June 30, 2016
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: André Rolim Baby
• Grantee: André Rolim Baby
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Camila Areias de Oliveira ; Daniela D Almeida Peres

Abstract

Considering especially the lips, chronicle exposition to UV radiation does not trigger the same skin defense mechanisms, such as tanning and stratum corneum hypertrophy. Therefore, the use of sunscreen lip balms is extremely important. The Faculty of Pharmaceutical Sciences (University of São Paulo) Cosmetology Group has been developing promising researches and scientific partnerships related to bioactive photoprotection. The group experience demonstrated there is a real necessity in studying complex systems presenting bioactive photoprotection activity, especially the association of UV filters with active natural substances - isolated or in the form of extracts/butters - once non elucidated events occur in the mentioned systems, for example, the increasing or decreasing of Sun Protection Factor (SPF) in the presence of some natural compounds. The aim of this study is the development and physical-chemical and functional evaluation of sunscreen lip balms containing ethylhexyl methoxycinnamate, titanium dioxide and shea butter (Butyrospermum parkii) as the bioactive compound. Specifically, the study purposes are: development of sunscreen lip balms by means of a factorial desing of experiment; physical and physical-chemical characteristics determination; functional properties evaluation by diffuse reflectance spectrophotometry with integrating sphere; and in vivo photoprotective efficacy, obtained by a globally recognized method. Additionally, the present study aims to promote the experimental refinement in Cosmetic Science research and scientific publication, in journals of high impact factor, considering the insertion area of this study and the photoprotection / bioactive photoprotection themes. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DANELUTI, ANDRE LUIS MAXIMO; GUERRA, LUCAS OFFENBECKER; VELASCO, MARIA VALERIA ROBLES; MATOS, JIVALDO DO ROSARIO; BABY, ANDRE ROLIM; KALIA, YOGESHVAR N.. Preclinical and clinical studies to evaluate cutaneous biodistribution, safety and efficacy of UV filters encapsulated in mesoporous silica SBA-15. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 169, p. 113-124, DEC 2021. (13/18689-5)

SARRUF, FERNANDA D.; CANDIDO, THALITA M.; DE OLIVEIRA, CAMILA A.; BOU-CHACRA, NADIA A.; ROBLES VELASCO, MARIA V.; BABY, ANDRE R.. Influence of Shea (Butyrospermum parkii) butter, TiO2 and ethylhexyl methoxycinnamate on physical parameters and in vitro photoprotective efficacy. Journal of Cosmetic Dermatology, v. 19, n. 8, DEC 2019. (13/18689-5)

MAXIMO DANELUTI, ANDRE LUIS; NETO, FRANCISCO MARIANO; RUSCINC, NADIA; LOPES, INGRID; ROBLES VELASCO, MARIA VALERIA; MATOS, JIVALDO DO ROSARIO; BABY, ANDRE ROLIM; KALIA, YOGESHVAR N.. Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters. International Journal of Pharmaceutics, v. 570, OCT 30 2019. (13/18689-5)

SARRUF, FERNANDA D.; SAUCE, RAFAEL; CANDIDO, THALITA M.; OLIVEIRA, CAMILA A.; ROSADO, CATARINA; VELASCO, MARIA V. R.; BABY, ANDRE R.. Butyrospermum parkii butter increased the photostability and in vivo SPF of a molded sunscreen system. Journal of Cosmetic Dermatology, v. 19, n. 12, MAY 2020. (13/18689-5)

ROSADO, CATARINA; TOKUNAGA, VIVIANE KAORI; SAUCE, RAFAEL; DE OLIVEIRA, CAMILA AREIAS; SARRUF, FERNANDA DAUD; PARISE-FILHO, ROBERTO; MAURICIO, ELISABETE; DE ALMEIDA, TENIA SANTOS; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant. FRONTIERS IN PHYSIOLOGY, v. 10, MAY 3 2019. (12/04435-9, 13/08535-0, 13/18689-5)