Cardiac rehabilitation in patients with refractory angina

• Grant number: 14/00345-0
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2014
• End date: March 31, 2017
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Luciana Diniz Nagem Janot de Matos
• Grantee: Luciana Diniz Nagem Janot de Matos
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Alexandre da Costa Pereira ; Camila Paixão Jordão ; Carlos Eduardo Negrão ; José Eduardo Krieger ; Luciana Oliveira Cascaes Dourado ; Luís Henrique Wolff Gowdak ; Luiz Antonio Machado Cesar ; Marcelo Luiz Campos Vieira

Abstract

Refractory angina is a chronic and disabling condition. The cardiac rehabilitation, although considered an alternative therapy, was previously little studied in this population. Objectives: Evaluation of the safety and feasibility of cardiac rehabilitation in patients with refractory angina, as well as its effect on VO2max and myocardial ischemic burden by exercise echocardiography. Secondary objectives: assessment of myocardial effort injury through troponin; effect on the sympathetic modulation and systemic inflammation, muscle blood flow and lipid metabolism; effect on ventricular function by exercise echocardiography; detection of ischemia and arrhythmias identified during rehabilitation sessions via telemetry; assessment of quality of life, functional class of angina (Canadian Cardiovascular Society), the number of angina episodes and daily consumption of sublingual nitrate. Methods: Clinical, prospective randomized controlled study, in patients between 45 and 75 years, who are on optimal medical therapy and are not candidates for revascularization, presence of myocardial ischemia documented by imaging method, and no contraindications to the practice of exercises. Patients will be randomized into 2 groups: 26 patients to optimal medical treatment group (MT) and 26 patients to the MT + exercise training group, for 12 weeks. The clinical, laboratory and imaging evaluation will be performed at inclusion and at the end of the protocol. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARLA GIULIANO DE SÁ PINTO MONTENEGRO; LUCIANA OLIVEIRA CASCAES DOURADO; CAMILA PAIXÃO JORDÃO; MARCELO LUIZ CAMPOS VIEIRA; CAMILA REGINA ALVES ASSUMPÇÃO; LUIS HENRIQUE WOLFF GOWDAK; ALEXANDRE DA COSTA PEREIRA; CARLOS EDUARDO NEGRÃO; LUCIANA DINIZ NAGEM JANOT DE MATOS. Ocorre Lesão Miocárdica após uma Sessão de Exercício Aeróbico Agudo em Pacientes com Angina Refratária?. Arquivos Brasileiros de Cardiologia, v. 119, n. 5, p. 747-753, 2022-11-25. (14/00345-0)