Recovery of victims of diffuse axonal injury and associated factors

• Grant number: 13/21804-0
• Support type: Regular Research Grants
• Duration: May 01, 2014 - April 30, 2016
• Field of knowledge: Health Sciences - Nursing - Medical-Surgical Nursing
• Principal researcher: Regina Marcia Cardoso de Sousa
• Grantee: Regina Marcia Cardoso de Sousa
• Home Institution: Escola de Enfermagem (EE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Assoc. researchers: Wellingson Silva Paiva

Abstract

The diffuse axonal injury (DAI) is a microscopic lesion of the axons of the cerebral hemispheres, the corpus callosum and brainstem who stands among traumatic injuries by severity of their consequences. However, there are few studies that describe the victims recovery of this injury and increase knowledge in this area is relevant to the introduction of new technical assistance, plan treatment and monitor the victims` evolution after this type of injury. Given these observations are objectives of this study describe the recovery of victims with a primary diagnosis of DAI up to six months after traumatic brain injury (TBI) and to identify demographic and clinical factors associated partners. Will be part of the study the DAI victims, age e 18 years, admitted in Medicine School Hospital of the Universidade de São Paulo (HCFMUSP) six hours after the traumatic event. There will be a prospective cohort study with four approaches to victims and family: in hospital, at discharge or transfer the patient to another hospital, three and six months after trauma. To evaluate the funcionality recovery of victims of DAI will be applied scales - Extended Glasgow Outcome Scale (GOS-E) and Disability Rating Scale (DRS), instruments that assess independence in activities of daily living (ADL)- Katz Index and Lawton and also a survey published in scientific literature and prepared to identify the behavioral changes after TBI. The score difference in the approaches of these instruments will characterize the programmed recovery observed and a multivariate analysis will be used to identify clinical and demographic factors associated with it. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SARDINHA, DEBORA SOUZA; ALMEIDA VIEIRA, RITA DE CASSIA; PAIVA, WELLINGSON SILVA; DE OLIVEIRA, DANIEL VIEIRA; CARDOSO DE SOUSA, REGINA MARCIA. Behavioral Changes and Associated Factors After Diffuse Axonal Injury. JOURNAL OF TRAUMA NURSING, v. 26, n. 6, p. 328-339, NOV-DEC 2019. Web of Science Citations: 0.

ALMEIDA VIEIRA, RITA DE CASSIA; PAIVA, WELLINGSON SILVA; DE OLIVEIRA, DANIEL VIEIRA; DE PAULA GUIRADO, VINICIUS MONTEIRO; CAETANO LANCA, ELLEN DE FATIMA; CARDOSO DE SOUSA, REGINA MARCIA. Recovery of Patients with Pure Diffuse Axonal Injury Who Remained in a Coma for 6 Hours or More. WORLD NEUROSURGERY, v. 109, p. 140-146, JAN 2018. Web of Science Citations: 1.

ALMEIDA VIEIRA, RITA DE CASSIA; PAIVA, WELLINGSON SILVA; DE OLIVEIRA, DANIEL VIEIRA; TEIXEIRA, MANOEL JACOBSEN; DE ANDRADE, ALMIR FERREIRA; CARDOSO DE SOUSA, REGINA MARCIA. Diffuse Axonal Injury: Epidemiology, Outcome and Associated Risk Factors. FRONTIERS IN NEUROLOGY, v. 7, OCT 20 2016. Web of Science Citations: 17.