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Longitudinal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury

Grant number: 17/17065-9
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): September 01, 2017
Effective date (End): November 30, 2019
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal researcher:Celi Santos Andrade
Grantee:Daphine Centola Grassi
Home Institution: Instituto de Radiologia (INRAD). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:15/18136-1 - Longitudinal multimodal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury, AP.JP

Abstract

Traumatic Brain Injury (TBI) is an important cause of morbidity and mortality, with serious economic and social consequences. Diffuse Axonal Injury (DAI) derives from rotational or shearing forces in brain parenchyma, and it is the pathological substrate in manypatients who require hospital admission. The surviving patients may present serious functional and cognitive impairment, often with poor quality of life and psychiatric symptoms. Magnetic Resonance Imaging (MRI) may demonstrate brain abnormalities related to DAI, but the conventional images underestimate the extent and severity of the lesions. Diffusion Tensor Imaging (DTI) is an advanced MRI sequence that may provide particular qualitative and quantitative information about brain microstructure and connectivity in vivo, and is also useful in monitoring disease progression. The main purpose of the study is to longitudinally evaluate the integrity of brain parenchyma of patients with moderate to severe DAI by taking advantage of multiple analytical methods of DTI and their correlations with clinical data, quality of life and neuropsychological tests. This work may help to understand the pathophysiology and progression of DAI and foster the development of new therapies and recovery of the quality of life of the affected patients. Furthermore, this project will be ofgreat value in promoting the use of analytical techniques of DTI in our scientific community, favoring its future application in other research projects for the study of diverse neurological diseases. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRASSI, DAPHINE CENTOLA; ZANINOTTO, ANA LUIZA; FELTRIN, FABRICIO STEWAN; MACRUZ, FABIOLA BEZERRA CARVALHO; OTADUY, MARIA CONCEPCION GARCIA; LEITE, CLAUDIA COSTA; GUIRADO, VINICIUS MONTEIRO PAULA; PAIVA, WELLINGSON SILVA; SANTOS ANDRADE, CELI. Dynamic changes in white matter following traumatic brain injury and how diffuse axonal injury relates to cognitive domain. BRAIN INJURY, JAN 2021. Web of Science Citations: 0.
DAPHINE CENTOLA GRASSI; DAVID MACEDO DA CONCEIÇÃO; CLAUDIA DA COSTA LEITE; CELI SANTOS ANDRADE. Current contribution of diffusion tensor imaging in the evaluation of diffuse axonal injury. Arquivos de Neuro-Psiquiatria, v. 76, n. 3, p. -, Mar. 2018.
GRASSI, DAPHINE CENTOLA; DA CONCEICAO, DAVID MACEDO; LEITE, CLAUDIA DA COSTA; ANDRADE, CELI SANTOS. Current contribution of diffusion tensor imaging in the evaluation of diffuse axonal injury. Arquivos de Neuro-Psiquiatria, v. 76, n. 3, p. 189-199, MAR 2018. Web of Science Citations: 4.
DAPHINE CENTOLA GRASSI; GRASIELA ROCHA BARROS DA SILVA; CELI SANTOS ANDRADE. Reply. Arquivos de Neuro-Psiquiatria, v. 76, n. 10, p. -, Out. 2018.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.