Colorectal cancer screening: a pilot study using Fecal Immunochemical Test (FIT)

• Grant number: 14/50112-2
• Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)
• Start date: July 01, 2014
• End date: December 31, 2016
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Agreement: CNPq - PPSUS
• Principal Investigator: José Eluf Neto
• Grantee: José Eluf Neto
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Screening is an action direct to the asymptomatic population in the subclinical phase of the problem in question. The purpose of screening is to reduce the incidence of cancer in the population, detecting the disease in its early stages dormant. Usually, the screening test is less invasive, so the operating characteristics of the test, coupled with the prevalence of the disease being screened, it is important to minimize the potential harm of screening in São Paulo, colorectal cancer (CRC) is the third most common cancer in men and women and the fourth most frequent cause of cancer death (INCA). At the Instituto do Cancer do Est ado de São Paulo (ICESP - HCFMUSP) more than 50% of patients presented with advanced colorectal cancer at moment of the diagnosis, stage IV with distant metastases. Objective: To conduct a pilot project of an organized screening program through a pre-defined investigation protocol of colorectal cancer (CRC) enrolled in the target population of the western region of São Paulo. Method: Individuals coming from the USP program at the West Zone of São Paulo, aged 50 to 70 years asymptomatic, will be called to realize an immunochemical fecal test, those patients whose outcome is positive, will be forwarded to the Institute Central HC FMUSP for a colonoscopy with biopsy if necessary. The cases diagnosed with malignancy by pathology will be forwarded to the Instituto do Cancer do Estado de São Paulo for cancer treatment. Expected results: determine whether the Fecal Immunochemical Test is effective in an organized screening Colorectal Cancer program. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ULYSSES RIBEIRO JR.; ADRIANA VAZ SAFATLE-RIBEIRO; MAURÍCIO SORBELLO; POLIANA HELENA ROSOLEM KISHI; DIANE DEDE COHEND; REJANE MATTAR; VERA LUCIA PAGLIUSI CASTILHO; ELENICE MESSIAS DO NASCIMENTO GONCALVES; FÁBIO KAWAGUTI; CARLOS FREDERICO SPARAPAN MARQUES; et al. Implementation of an organized colorectal cancer screening program through quantitative fecal immunochemical test followed by colonoscopy in an urban low-income community: Guidance and strategies. Clinics, v. 78, 2023-10-20. (14/50112-2)