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Effectiveness and safety of colorectal cancer screening using fecal occult blood test for adults aged from 45 to 75 years: a systematic review

Grant number: 19/19386-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2020
Effective date (End): April 30, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Vania dos Santos Nunes Nogueira
Grantee:Luiza Teixeira Soares
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Colorectal cancer (CRC) comprises malignant neoplasms originating in the colon or rectum, becoming an increasingly prevalent disease and responsible for a large portion of cancer deaths worldwide. Its early diagnosis allows to initiate the treatment in earlier cancer stages, reducing its morbidity and mortality. This study aims to evaluate the effectiveness and safety of CRC population screening by fecal occult blood test in adults aged from 45 to 75 years old. To this end, a systematic review will be conducted according to the Cochrane collaboration, in which asymptomatic individuals with standard risk for CRC underwent one of the fecal occult blood tests. The control group is composed by individuals without screening and the primary outcomes are overall and CRC mortality.