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Preparation, characterization and biological evaluations of mono and bimetallic nanoparticles systems


The present project is focused on the synthesis, characterization and evaluation of cytotoxicity of metallic and bimetallic Fe and Au nanoparticles. For this end, we will study the morphological, structural and magnetic properties of metallic iron nanoparticles synthesized by the methods of co-precipitation and thermodecomposition. We intend to investigate the synthesis parameters, relating them with the characteristics of the produced nanoparticles (NPs) in order to improve their biocompatibility, when compared to results found in the literature, and thus evaluating its applicability in biomedicine. The objective is to implement a research line that involves the investigation of the thermodecomposition of Fe- and Au-containing ligands coordination compounds such as acetylacetonate and acetate to produce metallic and bimetallic NPs of Fe and Au with different morphologies and a size distribution from 4 to 30 nm. The goal of this first step is to explore the mechanisms of nucleation and the factors that influence the structure, morphology and the magnetic characteristics of this class of compounds, since they directly influence their properties. The synthesis method by co-precipitation of salts will be employed. Morphological, structural and magnetic characterization as well as the efficiency of functionalization of ligands on the surface of the NPs will be performed by different techniques. The second step in this project focuses on the use of these systems as vehicles for releasing nitric oxide (NO) and photoactive molecules, which are used as anti-tumors agents. Thus, we intended to functionalize the surface of the NPs with thiol groups -SH groups and silicates (SiO2). We will also consider the cytotoxicity of NPs in cultures of tumor and healthy cells. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEMOS PEREIRA, GUILHERME FERREIRA; COSTA, FANNY NASCIMENTO; SOUZA, JOSE ANTONIO; HADDAD, PAULA SILVIA; FERREIRA, FABIO FURLAN. Parametric Rietveld refinement and magnetic characterization of superparamagnetic iron oxide nanoparticles. Journal of Magnetism and Magnetic Materials, v. 456, p. 108-117, JUN 15 2018. Web of Science Citations: 2.
PELEGRINO, MILENA T.; DE ARAUJO, DANIELE R.; SEABRA, AMEDEA B. S-nitrosoglutathione-containing chitosan nanoparticles dispersed in Pluronic F-127 hydrogel: Potential uses in topical applications. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 43, p. 211-220, FEB 2018. Web of Science Citations: 7.
PELEGRINO, MILENA T.; SILVA, LETECIA C.; WATASHI, CAROLINA M.; HADDAD, PAULA S.; RODRIGUES, TIAGO; SEABRA, AMEDEA B. Nitric oxide-releasing nanoparticles: synthesis, characterization, and cytotoxicity to tumorigenic cells. JOURNAL OF NANOPARTICLE RESEARCH, v. 19, n. 2 FEB 8 2017. Web of Science Citations: 12.
FUDIMURA, KARINA A.; SEABRA, AMEDEA B.; SANTOS, MARCONI C.; HADDAD, PAULA S. Synthesis and Characterization of Methylene Blue-Containing Silica-Coated Magnetic Nanoparticles for Photodynamic Therapy. Journal of Nanoscience and Nanotechnology, v. 17, n. 1, p. 133-142, JAN 2017. Web of Science Citations: 4.
GONCALVES, L. C.; SEABRA, A. B.; PELEGRINO, M. T.; DE ARAUJO, D. R.; BERNARDES, J. S.; HADDAD, P. S. Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications. RSC ADVANCES, v. 7, n. 24, p. 14496-14503, 2017. Web of Science Citations: 19.
HADDAD, PAULA S.; SANTOS, MARCONI C.; DE GUZZI CASSAGO, CAROLINA APARECIDA; BERNARDES, JULIANA S.; DE JESUS, MARCELO BISPO; SEABRA, AMEDEA B. Synthesis, characterization, and cytotoxicity of glutathione-PEG-iron oxide magnetic nanoparticles. JOURNAL OF NANOPARTICLE RESEARCH, v. 18, n. 12 DEC 10 2016. Web of Science Citations: 6.
SANTOS, M. C.; SEABRA, A. B.; PELEGRINO, M. T.; HADDAD, P. S. Synthesis, characterization and cytotoxicity of glutathione- and PEG-glutathione-superparamagnetic iron oxide nanoparticles for nitric oxide delivery. Applied Surface Science, v. 367, p. 26-35, MAR 30 2016. Web of Science Citations: 22.
SEABRA, ARNEDEA B.; JUSTO, GISELLE Z.; HADDAD, PAULA S. State of the art, challenges and perspectives in the design of nitric oxide-releasing polymeric nanomaterials for biomedical applications. BIOTECHNOLOGY ADVANCES, v. 33, n. 6, 3, SI, p. 1370-1379, NOV 1 2015. Web of Science Citations: 49.

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