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Evaluation of circulating levels of Glucagon-like-peptide 1 and 2 in human subjects with Crohns Disease

Grant number: 14/06164-8
Support Opportunities:Regular Research Grants
Duration: August 01, 2014 - July 31, 2016
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Claudio Saddy Rodrigues Coy
Grantee:Claudio Saddy Rodrigues Coy
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Daniéla Oliveira Magro

Abstract

Evaluation of circulating levels of Glucagon-like-peptide 1 and 2 in human subjects with Crohns disease.- Intestinal resection in Crohns disease can reach up to 80% of the patients and be associated with disabsortive syndrome. Glucagon-like-peptide 1 and 2 (GLP-1 e GLP-2) are produced in enterocytes throughout the small bowel and ascending colon in response to nutrient ingestion. It is speculated that circulating levels of GLP-1 and GLP-2 may be altered in cases of intestinal resection and disease activity, however, there are few studies about this matter in Crohn' disease. Our objective is determine serum levels of GLP-1 and GLP-2 and DPP-4 in patients with Crohns disease, in an outpatient unit (GASTROCENTRO - UNICAMP). The patients will be evaluated according to the Crohns disease active index, nutritional status and submitted to meal tolerance test. This research may contribute to better knowledge of these incretins in Crohn' disease. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAGRO, DANIELA OLIVEIRA; KOTZE, PAULO GUSTAVO; REAL MARTINEZ, CARLOS AUGUSTO; CAMARGO, MICHEL GARDERE; GUADAGNINI, DIOZE; CALIXTO, ANTONIO RAMOS; JUNQUEIRA VASQUES, ANA CAROLINA; SETSUKO AYRIZONO, MARIA DE LOURDES; GELONEZE, BRUNO; PAREJA, JOSE CARLOS; et al. Changes in serum levels of lipopolysaccharides and CD26 in patients with Crohn's disease. INTESTINAL RESEARCH, v. 15, n. 3, p. 352-357, . (14/06164-8)
MAGRO, DANIELA OLIVEIRA; CAZZO, EVERTON; KOTZE, PAULO GUSTAVO; JUNQUEIRA VASQUES, ANA CAROLINA; REAL MARTINEZ, CARLOS AUGUSTO; CHAIM, ELINTON ADAMI; GELONEZE, BRUNO; PAREJA, JOSE CARLOS; RODRIGUES COY, CLAUDIO SADDY. Glucose Metabolism Parameters and Post-Prandial GLP-1 and GLP-2 Release Largely Vary in Several Distinct Situations: a Controlled Comparison Among Individuals with Crohn's Disease and Individuals with Obesity Before and After Bariatric Surgery. OBESITY SURGERY, v. 28, n. 2, p. 378-388, . (14/06164-8)

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