Development and evaluation of topical formulations for oral mucositis treatment containing Spilanthol

• Grant number: 14/16186-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2015
• End date: January 31, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Rodney Alexandre Ferreira Rodrigues
• Grantee: Rodney Alexandre Ferreira Rodrigues
• Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil

Abstract

Spilanthol or afinin is an alkylamide found in herbs, among them, Spilanthes acmella (L.) L., and have several pharmacological properties such as anti-inflammatory, anesthetic and antioxidant activities. These properties may be of great interest in the treatment of oral mucositis, a typical side effect due to the treatment of cancer patients undergoing radiation and chemotherapy. The aim of this work is to obtain oral formulations to combat mucositis, with the incorporation of spilanthol obtained by supercritical extraction and evaluate their anti-inflammatory activity through experimental models. For this purpose different bioadhesives will be selected to choose the most suitable for oral use, with properties such as flexibility, elasticity, color, taste and controlled release of spilanthol, that can bring comfort to the patient by avoiding the frequent change. Experiments in vitro and also anti-inflammatory and antinociceptive activities in vivo models of paw edema induced by carrageenan and gastrointestinal mucositis with subsequent histopathological analysis will also be performed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE FREITAS BLANCO, VERONICA SANTANA; MICHALAK, BARBARA; MACCARI ZELIOLI, ICARO AUGUSTO; SANTOS DE OLIVEIRA, ADRIANA DA SILVA; NOVA RODRIGUES, MARILI VILLA; FERREIRA, ANTONIO GILBERTO; GARCIA, VERA LUCIA; CABRAL, FERNANDO ANTONIO; KISS, ANNA KAROLINA; FERREIRA RODRIGUES, RODNEY ALEXANDRE. Isolation of spilanthol from Acmella oleracea based on Green Chemistry and evaluation of its in vitro anti-inflammatory activity. JOURNAL OF SUPERCRITICAL FLUIDS, v. 140, p. 372-379, OCT 2018. (14/06461-2, 15/09644-3, 14/07225-0, 14/16186-9)

DE FREITAS-BLANCO, VERONICA SANTANA; MONTEIRO, KARIN MAIA; DE OLIVEIRA, PATRICIA ROSA; SOUZA DE OLIVEIRA, ELLEN CRISTINA; DE OLIVEIRA BRAGA, LUCIA ELAINE; DE CARVALHO, JOAO ERNESTO; FERREIRA RODRIGUES, RODNEY ALEXANDRE. Spilanthol, the Principal Alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Planta Medica, v. 85, n. 3, p. 203-209, FEB 2019. (14/16186-9, 14/06461-2)

ALONSO, ISABELLA G.; YAMANE, LAIS T.; DE FREITAS-BLANCO, VERONICA S.; NOVAES, LUIZ F. T.; FRANZ-MONTAN, MICHELLE; DE PAULA, ENEIDA; RODRIGUES, MARILI V. N.; RODRIGUES, RODNEY A. F.; PASTRE, JULIO C.. A new approach for the total synthesis of spilanthol and analogue with improved anesthetic activity. Tetrahedron, v. 74, n. 38, p. 5192-5199, SEP 20 2018. (15/08199-6, 14/06461-2, 14/25770-6, 14/16186-9, 14/26378-2)

Filed patent(s) as a result of this research project