Abstract
Ticks have parasitic habit of life, feeding obligatory on blood and/or lymph of vertebrates. As a result of hematophagy, these arthropods transmit a wide variety of pathogens. Among the tick-borne rickettsial diseases, we highlight Bovine Anaplasmosis (BA) and Brazilian Spotted Fever (BSF). BA is a severe disease that affects cattle, being caused by Anaplasma marginale and transmitted by Rhipicephalus microplus in Brazil. Despite the veterinary and economic importance, there is no commercial vaccine for the control of either R. microplus or BA. Similarly, there is no vaccine for prevention of BSF, the most severe rickettsial disease that affects humans. In our country, the etiologic agent of BSF, Rickettsia rickettsii, is transmitted by ticks of the genus Amblyomma. This project aims to elucidate the molecular factors involved in the interaction among ticks and rickettsiae with the participation of a consistent network of researchers with complementary expertises. The generated data may reveal new targets for the development of vaccines for the control of both ticks and BA and BSF. In addition, we propose to investigate the susceptibility of A. marginale to antimicrobial components, enabling a more effective control of BA through chemoprophylaxis which is more frequently used in combination with vaccination. (AU)
Scientific publications
(13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FOGACA, ANDREA C.;
SOUSA, GESSICA;
PAVANELO, DANIEL B.;
ESTEVES, ELIANE;
MARTINS, LARISSA A.;
URBANOVA, VERONIKA;
KOPACEK, PETR;
DAFFRE, SIRLEI.
Tick Immune System: What Is Known, the Interconnections, the Gaps, and the Challenges.
FRONTIERS IN IMMUNOLOGY,
v. 12,
MAR 2 2021.
Web of Science Citations: 0.
MARTINS, LARISSA ALMEIDA;
PALMISANO, GIUSEPPE;
CORTEZ, MAURO;
KAWAHARA, REBECA;
DE FREITAS BALANCO, JOSE MARIO;
FUJITA, ANDRE;
ALONSO, BEATRIZ IGLESIAS;
BARROS-BATTESTI, DARCI MORAES;
BRAZ, GLORIA REGINA CARDOSO;
TIRLONI, LUCAS;
ESTEVES, ELIANE;
DAFFRE, SIRLEI;
FOGACA, ANDREA CRISTINA.
The intracellular bacterium Rickettsia rickettsii exerts an inhibitory effect on the apoptosis of tick cells.
PARASITES & VECTORS,
v. 13,
n. 1
DEC 1 2020.
Web of Science Citations: 0.
ESTEVES, ELIANE;
FONGSARAN, CHANIDA;
LANGOHR, INGEBORG M.;
RILEY, SEAN P.;
LABRUNA, MARCELO B.;
DAFFRE, SIRLEI;
FOGACA, ANDREA C.;
MACALUSO, KEVIN R.
Comparative Analysis of Infection by Rickettsia rickettsii Sheila Smith and Taiacu Strains in a Murine Model.
PATHOGENS,
v. 9,
n. 9
SEP 2020.
Web of Science Citations: 0.
PAVANELO, DANIEL B.;
SCHRODER, NICOLAS C. H.;
PIN VISO, NATALIA D.;
MARTINS, LARISSA A.;
MALOSSI, CAMILA D.;
GALLETTI, MARIA F. B. M.;
LABRUNA, MARCELO B.;
DAFFRE, SIRLEI;
FARBER, MARISA;
FOGACA, ANDREA C.
Comparative analysis of the midgut microbiota of two natural tick vectors of Rickettsia rickettsii.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,
v. 106,
MAY 2020.
Web of Science Citations: 0.
MARTINS, LARISSA A.;
MALOSSI, CAMILA D.;
GALLETTI, MARIA F. B. DE M.;
RIBEIRO, JOSE M.;
FUJITA, ANDRE;
ESTEVES, ELIANE;
COSTA, FRANCISCO B.;
LABRUNA, MARCELO B.;
DAFFRE, SIRLEI;
FOGACA, ANDREA C.
The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection.
FRONTIERS IN PHYSIOLOGY,
v. 10,
MAY 3 2019.
Web of Science Citations: 1.
ESTEVES, ELIANE;
BIZZARRO, BRUNA;
COSTA, FRANCISCO BORGES;
RAMIREZ-HERNANDEZ, ALEJANDRO;
FERRANTI PETI, ANA PAULA;
DEPIERI CATANEO, ALLAN HENRIQUE;
WOWK, PRYSCILLA FANINI;
TIMOTEO, RODOLFO PESSATO;
LABRUNA, MARCELO BAHIA;
SILVA JUNIOR, PEDRO ISMAEL;
SILVA, CELIO LOPES;
FACCIOLI, LUCIA HELENA;
FOGACA, ANDREA CRISTINA;
SORGI, CARLOS ARTERIO;
SA-NUNES, ANDERSON.
Amblyomma sculptum Salivary PGE(2) Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo.
FRONTIERS IN IMMUNOLOGY,
v. 10,
FEB 4 2019.
Web of Science Citations: 0.
ESTEVES, ELIANE;
MARUYAMA, SANDRA R.;
KAWAHARA, REBECA;
FUJITA, ANDRE;
MARTINS, LARISSA A.;
RIGHI, ADNE A.;
COSTA, FRANCISCO B.;
PALMISANO, GIUSEPPE;
LABRUNA, MARCELO B.;
SA-NUNES, ANDERSON;
RIBEIRO, JOSE M. C.;
FOGACA, ANDREA C.
Analysis of the Salivary Gland Transcriptome of Unfed and Partially Fed Amblyomma sculptum Ticks and Descriptive Proteome of the Saliva.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,
v. 7,
NOV 21 2017.
Web of Science Citations: 11.
MARTINS, LARISSA A.;
DE MELO GALLETTI, MARIA F. B.;
RIBEIRO, JOSE M.;
FUJITA, ANDRE;
COSTA, FRANCISCO B.;
LABRUNA, MARCELO B.;
DAFFRE, SIRLEI;
FOGACA, ANDREA C.
The Distinct Transcriptional Response of the Midgut of Amblyomma sculptum and Amblyomma aureolatum Ticks to Rickettsia rickettsii Correlates to Their Differences in Susceptibility to Infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,
v. 7,
APR 28 2017.
Web of Science Citations: 5.
GALLETTI, MARIA FERNANDA B. M.;
FUJITA, ANDRE;
ROSA, RAFAEL D.;
MARTINS, LARISSA A.;
SOARES, HERBERT S.;
LABRUNA, MARCELO B.;
DAFFRE, SIRLEI;
FOGACA, ANDREA C.
Virulence genes of Rickettsia rickettsii are differentially modulated by either temperature upshift or blood-feeding in tick midgut and salivary glands.
PARASITES & VECTORS,
v. 9,
JUN 10 2016.
Web of Science Citations: 7.
ROSA, RAFAEL D.;
CAPELLI-PEIXOTO, JANAINA;
MESQUITA, RAFAEL D.;
KALIL, SANDRA P.;
POHL, PAULA C.;
BRAZ, GLORIA R.;
FOGACA, ANDREA C.;
DAFFRE, SIRLEI.
Exploring the immune signalling pathway-related genes of the cattle tick Rhipicephalus microplus: From molecular characterization to transcriptional profile upon microbial challenge.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,
v. 59,
p. 1-14,
JUN 2016.
Web of Science Citations: 14.
ESTEVES, E.;
POHL, P. C.;
KLAFKE, G. M.;
RECK, J.;
FOGACA, A. C.;
MARTINS, J. R.;
DAFFRE, S.
Low temperature affects cattle tick reproduction but does not lead to transovarial transmission of Anaplasma marginale.
Veterinary Parasitology,
v. 214,
n. 3-4,
p. 322-326,
DEC 15 2015.
Web of Science Citations: 2.