Evaluation of inpiratory and expiratory muscles in respiratory diseases

• Grant number: 14/50458-6
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2014
• End date: September 30, 2015
• Field of knowledge: Health Sciences - Medicine
• Agreement: Imperial College, UK
• Principal Investigator: Pedro Caruso
• Grantee: Pedro Caruso
• Principal researcher abroad: Nick Hopkinson
• Institution abroad: Imperial College London, England
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 10/08947-9 - Evaluation of INS and expiratory muscles in respiratory diseases, AP.TEM

Abstract

The study of the kinematics of the respiratory musculature (ins and expiratory) and its functional and clinical outcomes in respiratory diseases has a significant scientific contribution. While the diaphragm is extremely rectified in COPD, it may have an excessive shortening of its muscle fibers in pulmonary fibrosis. The ventilatory muscles also have crucial role in other clinical situations, such as weaning from mechanical ventilation and paralysis of the diaphragm. Therefore, there is a scientific relevance conducting investigations of respiratory mechanics, specifically the ventilatory muscles in different respiratory diseases. Considering also the need for centers with such an approach mainly in Brazil, we proposed this project that consists of four studies: (1) individuals with COPO, (2) with pulmonary fibrosis (3) in weaning from mechanical ventilation, and (4) in diaphragmatic paralysis. Outstanding diagnostic techniques are applied, as the maximum electromagnetic phrenic nerve stimulation, measurement of transdiaphragmatic pressure, and electromyography of accessory inspiratory muscles and expiratory, assessment of synchrony of thoracic subcompartments during respiratory cycles, all of that at rest and also during a maximal cardiopulmonary test. We aim to have a better pathophysiological understanding in these different clinical conditions, and consequently design new interventions for their respiratory problems. (AU)