Rabies in terrestrial wild fauna from de Northeast region of Brazil: molecular epidemiology and detection of immune response

• Grant number: 14/16333-1
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2015
• End date: August 31, 2017
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Silvana Regina Favoretto
• Grantee: Silvana Regina Favoretto
• Host Institution: Instituto Pasteur (IP). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Edison Luiz Durigon

Abstract

Although it is one of the most ancient diseases related in human history, rabies still presents a great challenge throughout the world. Wild animals have emergent importance in Brazil, and in this context the Northeast region of the Country has the better model to the epidemiologic study of wildlife rabies. In this region, the two independent virus variants maintained by terrestrial wildlife and presenting annual records of cases in the reservoirs species, other domestic and wild species and humans. These variants were initially identified in the State of Ceara and, to the present moment, are restricted to the Northeast region. The present study will be conducted by antigenic and molecular characterization of samples of the virus isolated from 14 cities endemic for wildlife rabies in Ceara State and by the detection of anti-rabies neutralizing antibodies in marmosets (Callithrix jacchus) and crab-eating-foxes (Cerdocyon thous) from the same State using different serologic techniques (Rapid Fluorescent Focus Inhibition Test - RFFIT, Simplified Fluorescent Inhibition Microtest - SFIMT and Fluorescent Antibody Virus Neutralization Test- FAVN). The aim of this study is the analysis of the laboratorial data obtained combined with information from the Epidemiological Surveillance Service from Ceara State, in order to provide information that will permit the implementation of more efficient measures for wildlife rabies prevention and control. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; MENDES, ERICA A.; LADNER, JASON T.; ANDREATA-SANTOS, ROBERT; ARAUJO, DANIELLE B.; BOTOSSO, VIVIANE F.; PAOLA, NICHOLAS D.; NETO, DANIEL F. L.; CUNHA, MARIELTON P.; et al. Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System. Viruses-Basel, v. 10, n. 11, NOV 2018. (13/07467-1, 14/17766-9, 14/27228-4, 14/16333-1, 16/08727-5, 15/25643-7, 14/03911-7, 16/08204-2, 16/20045-7, 13/26942-2, 16/03605-9)

FAVORETTO, SILVANA R.; ARAUJO, DANIELLE B.; DUARTE, NAYLE F. H.; OLIVEIRA, DANIELLE B. L.; DA CRUS, NATHALIA G.; MESQUITA, FLAVIO; LEAL, FABYANO; MACHADO, RAFAEL R. G.; GAIO, FERNANDA; OLIVEIRA, WALBER F.; et al. Zika Virus in Peridomestic Neotropical Primates, Northeast Brazil. ECOHEALTH, v. 16, n. 1, p. 61-69, MAR 2019. (14/16333-1)